Projects (42)

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Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)
Duration of Project: 02/2021 - 01/2024
Financer: DFG: Sachbeihilfe
Hackbarth, Steffen, Dr. rer. nat. (Experimental Physics / Photobiophysics)
Duration of Project: 11/2018 - 10/2020
Financer: Sonstige Stiftungen
Subject of the planned work is the optical, time-resolved detection of singlet oxygen phosphorescence, the extremely weak emission of the central protagonist of photodynamic tumor therapy (PDT). Three subtasks are to be solved within the project.
1. ...
Hackbarth, Steffen, Dr. rer. nat. (Experimental Physics / Photobiophysics)
Duration of Project: 02/2019 - 04/2019
Financer: DFG: Sonstiges
The 3nd Chinese-German Workshop on Singlet Oxygen and Photodynamic Effects will be held on 8-13 April 2019, in Fuzhou city in Fujian Porvince, China, which is a completely independent meeting. The aim is to provide a bilateral scientific and technica ...
Klipp, Edda, Prof. Dr. rer. nat. Dr. h.c. (Theoretical Biophysics)
Duration of Project: 02/2018 - 07/2018
Financer: Sonstige Stiftungen
The aim of the Advanced Lecture Course on Systems Biology is to bring in contact young researchers from different areas to the field of systems biology. Around 30 teachers present their knowledge to around 120 predocs and young scientists in talks, p ...
Klipp, Edda, Prof. Dr. rer. nat. Dr. h.c. (Theoretical Biophysics)
Duration of Project: 03/2020 - 03/2020
Financer: Stiftung
Der Advanced Lecture Course in Systems Biology hat zum Ziel, jungen Forschern aus unterschiedlichen Fachgebieten das Feld der Systembiologie näer zu bringen. Ca 30 Lehrende präsentieren ihr Wissen ca. 120 Doktoranden und Doktorandinnen sowie jungen W ...
Schneider, Erwin, Prof. Dr. rer. nat. (Physiology of Microorganisms)
Duration of Project: 07/2016 - 01/2021
Financer: DFG: Sachbeihilfe
Canonical ABC transport systems mediating the uptake of solutes in prokaryotes are composed of an extracytoplasmic solute binding protein, two pore-forming subunits and an ATPase dimer. Our current knowledge on the mechanism of Type I importers is la ...
Kshirsagar, Rucha, Dr. Ph.D. (Molecular Cell Biology)
Duration of Project: 10/2018 - 06/2022
Financer: DFG: Eigene Stelle (Sachbeihilfe)
Schäffner, Wolfgang, Prof. Dr. phil. (Knowledge and Cultural History)
Duration of Project: 07/2016 - 12/2016
Financer: Einstein Stiftung Berlin
The kick-off event "ANIMATION - designing movement", supported by the Einstein Foundation Berlin, brought together the science illustrators Amir Andikfar and Jonas Lauströer, the biologist John A. Nyakatura and the animation designer Nicolas Deveaux ...
Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)
Duration of Project: 09/2019 - 09/2019
Financer: DFG: Sonstiges
The discovery of the clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins in bacteria and archaea and the successful application of such CRISPR-Cas systems as a tool for genome editing have revoluti ...
Reber, Simone, (Integrative Research Institute for the Life Sciences (IRILS))
Duration of Project: 05/2018 - 07/2021
Financer: DFG: Sachbeihilfe
The goal of this research proposal is to understand the way in which cells engineer micrometerscale structures. In particular, we aim to understand how different force generating systems collectively define the shape of the metaphase spindle. The bip ...
SZF-1, Leitung Servicezentrum Forschung, (Research Service Centre)
Duration of Project: 01/2019 - 12/2025
Financer: DFG Exzellenzstrategie: Cluster
The central scientific objective of UniSysCat (Unifying Systems in Catalysis) is to master the next stage of future challenges in catalysis: how to elucidate, create, and control reaction networks in chemical and biological catalysis at different lev ...
SZF-1, Leitung Servicezentrum Forschung, (Research Service Centre)
Duration of Project: 01/2019 - 12/2025
Financer: DFG Exzellenzstrategie: Cluster
Neurological and psychiatric disorders pose a massive burden to society, and our understanding of the underlying molecular and pathophysiological mechanisms is limited. In addition, translation of knowledge into clinical advances has proven difficult ...
Romanczuk, Pawel, Dr. (Junior Research Groups)
Duration of Project: 06/2016 - 04/2021
Financer: DFG: Nachwuchsgruppe
The main objective of the project is the development and analysis of new individual based mathematical models of collective motion, which explicitly take the sensory perception into account, as the proximate mechanism of social interactions. This app ...
Romanczuk, Pawel, Dr. (Junior Research Groups)
Duration of Project: 11/2020 - 10/2021
Financer: DFG: Nachwuchsgruppe
The main objective of the project is the development and analysis of new individual based mathematical models of collective motion, which explicitly take the sensory perception into account, as the proximate mechanism of social interactions. This app ...
Romanczuk, Pawel, Dr. (Junior Research Groups)
Duration of Project: 05/2019 - 08/2021
Financer: DFG: Nachwuchsgruppe
The main objective of the project is the development and analysis of new individual based mathematical models of collective motion, which explicitly take the sensory perception into account, as the proximate mechanism of social interactions. This app ...
Dobbek, Holger, Prof. Dr. rer. nat. (Structural Biology / Biochemistry)
Duration of Project: 01/2017 - 12/2020
Financer: DFG - Schwerpunktprogramme
Anaerobic bacteria and archaea use homologous enzymes to convert CO2 and H2 to acetyl-CoA and methane, which determine since the dawn of life the global carbon cycle on earth. At first we want to investigate whether the homologous enzymes from archae ...
Zouni, Athina, (Experimental Biophysics)
Duration of Project: 01/2013 - 03/2021
Financer: DFG: Sonderforschungsbereich - Beteiligungen
In oxygenic photosynthesis, water is oxidized and dioxygen is formed at the Mn4Ca complex of photosystem II (PSII), a 750 kDa protein-cofactor complex embedded in the thylakoid membrane of plants and cyanobacteria. Reliable structural models of PSII ...
Erhardt, Marc, Prof. Dr. (Bacterial Physiology)
Duration of Project: 01/2020 - 12/2024
Financer: Volkswagen-Stiftung (VW)
Cell decision-making is the process of cells changing their phenotype according to their intrinsic programming and in response to the microenvironmental cues. Currently, little is known about the principles dictating cell decision-making in multicell ...
Fröbisch, Nadia, Prof. Dr. (Development and Evolution)
Duration of Project: 01/2019 - 12/2020
Financer: DAAD
An understanding of the mechanisms underlying the regenerative programs of limb/fin and tail regeneration in vertebrates are for obvious reasons of great interest and a major research focus of the fields of molecular biology and regenerative medicine ...
Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)
Duration of Project: 11/2018 - 10/2021
Financer: DFG: Sachbeihilfe
tRNAs are subject to a variety of chemical modifications that modulate their function in translation. In this project, we have investigated two such modifications, queuosine (Q) and cytosine-5 methylation (m5C). Our earlier work in Schizosaccharomyce ...
Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of Project: 11/2017 - 12/2018
Financer: DFG-Exzellenzinitiative: Cluster
Oxygen photosynthesis in green plants, algae and cyanobacteria is catalyzed by the two large membrane protein complexes Photosystem I (PSI) and Photosystem II (PSII). Both complexes contain a reaction center (RC) that conducts a light-driven charge t ...
Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of Project: 01/2019 - 12/2022
Financer: DFG-Exzellenzinitiative: Cluster
Oxygen photosynthesis in green plants, algae and cyanobacteria is catalyzed by two large membrane protein complexes Photosystem I (PSI) and Photosystem II (PSII). Both complexes contain a reaction center (RC) that conducts a light-driven charge trans ...
Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of Project: 11/2012 - 10/2017
Financer: DFG-Exzellenzinitiative: Cluster
Photosystem II (PSII) of oxygenic photosynthesis has the unique capability of utilizing visible light to oxidize water at the Mn4CaO5-cluster (the water oxidizing complex, WOC). Important progress in elucidating the molecular structure of the WOC has ...
Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)
Duration of Project: 08/2013 - 07/2014
Financer: DFG: Sachbeihilfe
Eukaryotic organisms require sophisticated mechanisms to ensure that gene expression in their genome is carried out in the correct temporal and spatial manner. Posttranslational histone modifications are one mechanism by which gene expression is cont ...
Garfield, David, Dr. (Junior Research Groups)
Duration of Project: 10/2019 - 09/2020
Financer: DAAD
Mutations impacting DNA regulatory elements make a disproportionate contribution to evolutionary processes and are important contributors to inter-individual variation in disease susceptibility.
We are, however, limited in our ability to predict *w ...
Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)
Duration of Project: 07/2019 - 09/2019
Financer: Sonstige Stiftungen
The discovery of the clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins in bacteria and archaea and the successful application of such CRISPR-Cas systems as a tool for genome editing have revoluti ...
Ohler, Uwe, Prof. Dr. (Systems Biology of Gene Regulation (S))
Duration of Project: 01/2019 - 06/2023
Financer: DFG: Graduiertenkollegs
The aim of the IRTG “Dissecting and Reengineering the Regulatory Genome” is to identify and characterise regulatory processes and DNA sequences that determine the activity of gene expression in eukaryotes. The researchers in Berlin, Germany, and Durh ...
Ohler, Uwe, Prof. Dr. (Systems Biology of Gene Regulation (S))
Duration of Project: 01/2019 - 06/2023
Financer: DFG: Graduiertenkollegs
The aim of the IRTG "Dissecting and Reengineering the Regulatory Genome" is to identify and characterise regulatory processes and DNA sequences that determine the activity of gene expression in eukaryotes. The researchers in Berlin, Germany, and Durh ...
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of Project: 10/2016 - 09/2021
Financer: Europäische Union (EU) - Monoprojekt
Channelrhodopsin which was discovered and described as a light-gated ion channel in my laboratory, has revolutionized the field of neuroscience over the past decade by enabling researchers to specifically activate selected neurons in a large ensemble ...
Eitinger, Thomas, Prof. Dr. rer. nat. (Microbiology)
Duration of Project: 04/2017 - 09/2020
Financer: DFG: Sachbeihilfe
Energy-coupling factor (ECF) transporters represent a large subgroup of the ATP-binding cassette (ABC) transporters and are involved in micronutrient uptake in prokaryotes. Substrates comprise water-soluble vitamins and the transition metal ions Co2+ ...
Dobbek, Holger, Prof. Dr. rer. nat. (Structural Biology / Biochemistry)
Duration of Project: 07/2019 - 06/2022
Financer: DFG: Sachbeihilfe
Ni, Fe-containing carbon monoxide dehydrogenases (CODHs) catalyze the reversible oxidation of CO with water to CO2, two protons and 2 electrons, e.g. allowing bacteria and archaea to convert CO2 to CO, which is condensed with a methyl-cation and CoA ...
Schäffner, Wolfgang, Prof. Dr. (Cluster of Excellence 'Matters of Activity')
Duration of Project: 01/2020 - 12/2021
Financer: DAAD
Neurosurgical practices are progressively guided by tomographic scanning technologies with increasing
anatomical details, such as magnetic resonance imaging (MRI). These tomographic image technologies
enable presurgical analysis and planning, as we ...
Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)
Duration of Project: 02/2020 - 01/2023
Financer: DFG: Sachbeihilfe
Centromeres are the regions of the chromosome where the kinetochore is assembled, and they establish a physical link between the centromeric chromatin and the microtubule for chromosome segregation in mitosis. In Saccharomyces cerevisiae, centromeric ...
Leser, Ulf, Prof. Dr.-Ing. (Knowledge Management in Bioinformatics)
Duration of Project: 06/2019 - 11/2023
Financer: DFG: Graduiertenkollegs - Beteiligungen
Recent advances in DNA sequencing and molecular profiling have triggered a major shift in cancer research. Traditional coarse-grained and phenomenological examinations and therapy decisions are replaced by individualized approaches that integrate mol ...
Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)
Duration of Project: 04/2019 - 09/2023
Financer: DFG: Graduiertenkollegs - Beteiligungen
The Research Training Group (RTG) “Bioactive Peptides – Innovative Aspects of Synthesis and Biosynthesis” aims to provide a structured curriculum on peptide research for doctoral students. In the past years, peptide research has become of significant ...
Hegemann, Peter, Prof. Dr. (Head of Department / Secretary)
Duration of Project: 07/2016 - 12/2019
Financer: BMBF
The aim of this project is the set-up of a novel end-station at the IRIS-beamline of BESSY II for simultaneous, microsecond time-resolved infra-red- and UV/Vis-spectroscopy of non-cyclic systems. The station will be used for first experiments in the ...
Röder, Beate, Prof. Dr. rer. nat. habil. (Experimental Physics / Photobiophysics)
Duration of Project: 05/2017 - 07/2017
Financer: DFG: Sonstiges
The 2nd Chinese-German Workshop on Singlet Oxygen and Photodynamic Effects will be held on 30th March until 2nd June 2017, in Berlin the capital of Germany, which is a completely independent meeting. The aim is to provide a bilateral scientific and t ...
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of Project: 09/2016 - 01/2019
Financer: DFG: Sachbeihilfe
The aim of this work is the development of novel optogenetic tools that allow investigations on subcellular compartments. In the first project, we will combine proton and chloride channels or chloride pumps with targeting motives for synaptic vesicle ...
Zouni, Athina, Dr. (Experimental Biophysics)
Duration of Project: 11/2013 - 10/2016
Financer: Sonstige internationale öffentliche Mittelgeber
The objective of this project is to study the overall protein structure and dynamics, as well as the chemical structure and dynamics of the oxygen-evolving complex (OEC) of the Photosystem II membrane bound protein, that catalyses the light-driven wa ...
Grimm, Bernhard, Prof. Dr. rer. nat. Prof. Dr. (Plant Physiology)
Duration of Project: 01/2021 - 12/2023
Financer: DFG: Sachbeihilfe
Chloroplasts primarily function as bioreactors converting light into chemical energy. In addition, they also act as regulatory hub for intracellular communication and mediation of environmental impacts to regulate nuclear gene expression. Chloroplast ...
Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of Project: 02/2018 - 01/2021
Financer: BMBF
The aims of the Tandem-project are light-triggered electrodes for efficient energy conversion. In the frame of the prolonged period of work it is planned to increase the efficiency of photobio-electrodes and also to couple them with enzymatic convers ...
Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of Project: 08/2013 - 10/2017
Financer: BMBF
The aim of the Tamdem-project is to develop light-activated electrode devices for biocatalytical purposes. Therefor photosystems or components should be combined with electrodes for an efficient phot-electron transfer. By coupling various enzyme syst ...
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