Projects (18)

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  • A New Generation of Microbial Expression Hosts and Tools for the Production of Biotherapeutics and High-Value Enzymes

    Klipp, Edda, Prof. Dr. rer. nat. Dr. h.c. (Theoretical Biophysics)

    Duration of Project: 01/2019 - 12/2022

    Financer: Europäische Union (EU) - HU als Beteiligte

    The challenge addressed in the SECRETERS programme is to markedly enhance the EU’s capacity for the production of secreted high-quality recombinant proteins, with a special emphasis on therapeutic proteins (biotherapeutics) and industrial enzymes tha ...

  • A Novel Lipid (Phosphatidylthreonine)-Regulated Calcium Homeostasis in Toxoplasma Gondii

    Gupta, Nishith, Dr. (Molecular Parasitology II)

    Duration of Project: 02/2019 - 01/2022

    Financer: DFG: Sachbeihilfe
    The major membrane glycerophospholipid classes, described thus far, include phosphatidylcholine,
    phosphatidylethanolamine, phosphatidylserine (PtdSer) and phosphatidylinositol. Our recent work has
    demonstrated the natural occurrence and genetic ori ...
  • Cyclic di-GMP in the Control of Multicellular Differentiation in Antibiotic-Producing Bacteria Streptomyces

    Tschowri, Natalia, Dr. rer. nat. (Junior Research Groups)

    Duration of Project: 12/2019 - 11/2020

    Financer: DFG: Nachwuchsgruppe

    Streptomyces are the most abundant source of clinically important antibiotics and other natural products used in human medicine. The production of these secondary metabolites is temporally and genetically coordinated with a complex developmental life ...

  • Deciphering the principles of cell decision-making in multicellular systems: The Least microEnvironmental Uncertainty Principle (LEUP)

    Erhardt, Marc, Prof. Dr. (Bacterial Physiology)

    Duration of Project: 01/2020 - 12/2024

    Financer: Volkswagen-Stiftung (VW)

    Cell decision-making is the process of cells changing their phenotype according to their intrinsic programming and in response to the microenvironmental cues. Currently, little is known about the principles dictating cell decision-making in multicell ...

  • Functional and Physiological Significance of Phosphatidylethanolamine Synthesis in the Protozoan Parasite Toxoplasma Gondii

    Gupta, Nishith, Dr. (Molecular Parasitology II)

    Duration of Project: 06/2019 - 09/2019

    Financer: DFG: Sonstiges
  • IRTG 2290/1: Crossing Boundaries: Molecular Interactions in Malaria

    Matuschewski, Kai, Prof. Dr. (Molecular Parasitology)

    Duration of Project: 09/2017 - 02/2022

    Financer: DFG: Graduiertenkollegs

    Malaria is caused by single-celled parasites known as Plasmodium, which are transmitted by the bite of the Anopheles mosquito. Some basic principles of the progress of the disease and parasite-host interactions are still not understood. The German-Au ...

  • Photoactive antimicrobial coatings

    Röder, Beate, Prof. Dr. rer. nat. habil. (Experimental Physics / Photobiophysics)

    Duration of Project: 04/2017 - 02/2020

    Financer: Bundesministerium für Wirtschaft und Technologie

    Metallische und mineralische Oberflächen an Häusern und technischen Gebäuden sind aufgrund ihrer Funktion oft jahrzehntelang Witterungseinflüssen ausgesetzt und damit Angriffspunkt für die unerwünschte Ansiedlung von Bakterien, Pilzen und Algen welch ...

  • Quality management in assembly of bacterial type III secretion systems – a comparative analysis of the construction of flagella and injectisomes

    Erhardt, Marc, Prof. Dr. (Bacterial Physiology)

    Duration of Project: 10/2019 - 09/2022

    Financer: DFG: Sachbeihilfe

    Protein export via type III secretion systems (T3SS) is essential for the self-assembly of bacterial flagella as well as for construction and function of virulence-associated injectisomes of many Gram-negative pathogens, including Salmonella enterica ...

  • RTG 2046/2: “Parasite Infections: From Experimental Models to Natural Systems”

    Matuschewski, Kai, Prof. Dr. (Molecular Parasitology II)

    Duration of Project: 10/2019 - 03/2024

    Financer: DFG: Graduiertenkollegs

    Parasites cause serious, health-depriving, disabling diseases affecting people and animals alike. These pathogens are globally distributed, prevalent, heterogeneous and extremely complex. There is a necessity and growing demand for interdisciplinaril ...

  • RTG 2046/2: “Parasite Infections: From Experimental Models to Natural Systems” (SP A2)

    Gupta, Nishith, Dr. (Molecular Parasitology II)

    Duration of Project: 10/2019 - 06/2021

    Financer: DFG: Graduiertenkollegs

    There is a growing gap in training opportunities in modern parasitology in Germany and beyond. This bottleneck is in clear contrast to the worldwide distribution of parasitic diseases in human and animal populations, with a steady increase due to dru ...

  • RTG 2046/2: “Parasite Infections: From Experimental Models to Natural Systems” (SP B1)

    Matuschewski, Kai, Prof. Dr. (Molecular Parasitology II)

    Duration of Project: 10/2019 - 03/2024

    Financer: DFG: Graduiertenkollegs

    There is a growing gap in training opportunities in modern parasitology in Germany and beyond. This bottleneck is in clear contrast to the worldwide distribution of parasitic diseases in human and animal populations, with a steady increase due to dru ...

  • RTG 2046/2: “Parasite Infections: From Experimental Models to Natural Systems” (TP C8)

    Heitlinger, Emanuel, Prof. Dr. rer. nat. (Ecology and Evolution molecularly Parasite-Host-Interactions)

    Duration of Project: 10/2019 - 03/2024

    Financer: DFG: Graduiertenkollegs

    There is a growing gap in training opportunities in modern parasitology in Germany and beyond. This bottleneck is in clear contrast to the worldwide distribution of parasitic diseases in human and animal populations, with a steady increase due to dru ...

  • Sensing in c-di-GMP signaling

    Hengge, Regine, Prof. Dr. (Microbiology)

    Duration of Project: 09/2019 - 08/2022

    Financer: DFG - Schwerpunktprogramme

    Signaltransduktion über sekundäre Botenstoffe beinhaltet primäre und sekundäre Signalwahrnehmung, da sowohl primäre Bedingungen – z.B. bestimmte Moleküle, Sauerstoff, Redoxsignale, Licht oder der Zustand eines Partnerproteins – die Synthese oder den ...

  • SPP 1879 - Nucleotide Second Messenger Signaling in Bacteria / Coordination

    Hengge, Regine, Prof. Dr. (Microbiology)

    Duration of Project: 09/2019 - 08/2022

    Financer: DFG - Schwerpunktprogramme

    The DFG priority programme SPP 1879 is a research consortium studying bacterial second messenger signaling that currently funds 18 research projects at German universities and other research institutions. By including representatives of all clades of ...

  • SPP 1879: Nucleotide Second Messenger Signaling in Bacteria / Coordination Project

    Hengge, Regine, Prof. Dr. (Microbiology)

    Duration of Project: 09/2016 - 08/2020

    Financer: DFG - Schwerpunktprogramme

    The overall goal of SPP 1879 over the next six years is to built a tightly collaborating and internationally radiating scientific community in the highly dynamic field of bacterial nucleotide second messenger signalling. Achieving this goal not only ...

  • SPP 1879: Sensory Mechanisms of c-di-GMP Signaling in E. coli Biofilm Formation

    Hengge, Regine, Prof. Dr. (Microbiology)

    Duration of Project: 09/2016 - 02/2020

    Financer: DFG - Schwerpunktprogramme

    Bacterial biofilms colonize diverse surfaces and are highly resistant against antibiotics or host immune systems. In these biofilms, cells are embedded in a self-produced protective matrix of extracellular biopolymers. Major biofilm matrix components ...

  • SPP 1879: The role of cyclic di-AMP and a novel cyclic di-nucleotide in differentiation and stress survival of Streptomyces spp.

    Tschowri, Natalia, Dr. rer. nat. (Microbiology)

    Duration of Project: 01/2017 - 05/2020

    Financer: DFG - Schwerpunktprogramme

    The Gram-positive soil bacteria streptomycetes belong to nature’s most competent ‘natural product factories’ and are an important source of diverse antibiotics and other bioactive molecules for medical, veterinary and agricultural use. The production ...

  • TWAS Malaria

    Matuschewski, Kai, Prof. Dr. (Molecular Parasitology)

    Duration of Project: 07/2017 - 09/2017

    Financer: DFG: Sonstiges

    Internationale wissenschaftliche Zusammenarbeit zwischen DFG und TWAS ( The World Academy of Sciences) zur Förderung eines maximal dreimonatigen Gastaufenthalts.

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