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Targeted Salix Crossing and Chemoprofiling for Improved Medicinal Potential of Willow Bark

Ulrichs, Christian, Prof. Dr. rer. nat.; Dr. rer. agr. (Urban Plant Ecophysiology)

Duration of Project: 07/2017 - 08/2021

Deforestation of Salix species for fuel as renewable sources for energetic use had priority in the past. However, the mobilization of dendromass from forests is limited and therefore, short-rotation plantations (SRP) with fast-growing tree species su ...

RTG 2473/1: Bioactive Peptides – Innovative Aspects of Synthesis and Biosynthesis

Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)

Duration of Project: 04/2019 - 09/2023

The Research Training Group (RTG) “Bioactive Peptides – Innovative Aspects of Synthesis and Biosynthesis” aims to provide a structured curriculum on peptide research for doctoral students. In the past years, peptide research has become of significant ...

RTG 2424/1: Computational Methods for Oncology: Towards Personalized Therapies in Cancer

Leser, Ulf, Prof. Dr.-Ing. (Knowledge Management in Bioinformatics)

Duration of Project: 06/2019 - 11/2023

Recent advances in DNA sequencing and molecular profiling have triggered a major shift in cancer research. Traditional coarse-grained and phenomenological examinations and therapy decisions are replaced by individualized approaches that integrate mol ...

RTG 2386/1: Extrospection: External Access to Higher Cognitive Processes.

Pauen, Michael, Prof. Dr. (Philosophy of Spirit)

Duration of Project: 10/2018 - 03/2023

Higher cognitive processes like emotions, perception, belief formation or mind-reading are of essential importance in philosophy, psychology, neuroscience, and psychiatry. It is quite controversial, though, to what extent these processes and particul ...

RTG 2046/2: Parasite Infections: From Experimental Models to Natural Systems (SP C08)

Heitlinger, Emanuel, Prof. Dr. rer. nat. (Ecology and Evolution molecularly Parasite-Host-Interactions)

Duration of Project: 10/2019 - 03/2024

There is a growing gap in training opportunities in modern parasitology in Germany and beyond. This bottleneck is in clear contrast to the worldwide distribution of parasitic diseases in human and animal populations, with a steady increase due to dru ...

RTG 2046/2: Parasite Infections: From Experimental Models to Natural Systems (SP B01)

Matuschewski, Kai, Prof. Dr. (Molecular Parasitology II)

Duration of Project: 10/2019 - 03/2024

There is a growing gap in training opportunities in modern parasitology in Germany and beyond. This bottleneck is in clear contrast to the worldwide distribution of parasitic diseases in human and animal populations, with a steady increase due to dru ...

RTG 2046/2: Parasite Infections: From Experimental Models to Natural Systems (SP A02)

Gupta, Nishith, Dr. (Molecular Parasitology II)

Duration of Project: 10/2019 - 06/2021

There is a growing gap in training opportunities in modern parasitology in Germany and beyond. This bottleneck is in clear contrast to the worldwide distribution of parasitic diseases in human and animal populations, with a steady increase due to dru ...

RTG 2046/2: Parasite Infections: From Experimental Models to Natural Systems

Matuschewski, Kai, Prof. Dr. (Molecular Parasitology II)

Duration of Project: 10/2019 - 03/2024

Parasites cause serious, health-depriving, disabling diseases affecting people and animals alike. These pathogens are globally distributed, prevalent, heterogeneous and extremely complex. There is a necessity and growing demand for interdisciplinary ...

RTG 2046/1: Parasite Infections: From Experimental Models to Natural Systems (SP B01)

Matuschewski, Kai, Prof. Dr. (Molecular Parasitology II)

Duration of Project: 05/2018 - 09/2019

Parasites cause serious, health-depriving, disabling diseases affecting people and animals alike. These pathogens are globally distributed, prevalent, heterogeneous and extremely complex. There is a necessity and growing demand for interdisciplinary ...

RTG 2046/1: Parasite Infections; From Experimental Models to Natural Systems (SP A04)

Heitlinger, Emanuel, Prof. Dr. rer. nat. (Ecology and Evolution molecularly Parasite-Host-Interactions)

Duration of Project: 04/2015 - 09/2019

The research training group studies molecular, ecological and evolutionary aspects of parasite infections of mammals. It scrutinizes whether laboratory models of parasite infections truly mirror the processes observed in natural systems. The research ...

RTG 2046/1: Parasite Infections: From Experimental Models to Natural Systems (SP A02)

Gupta, Nishith, Dr. (Molecular Parasitology)

Duration of Project: 04/2015 - 09/2019

With a steady increase due to drug resistance, global warming and increasing international travel, parasitic diseases are distributed world-wide in human and animal populations. The RTG aims to install a cutting edge and integrative curriculum to edu ...

RTG 1772/2: Computational Systems Biology

Klipp, Edda, Prof. Dr. rer. nat. Dr. h.c. (Theoretical Biophysics)

Duration of Project: 08/2015 - 01/2020

Biology has turned into a quantitative, information-driven science. Like physics in the first half of the twentieth century, biology now generates very challenging questions and masses of data that drive the development of theory and technology. Ther ...

RTG 1589/2: Sensory Computation in Neural Systems

Brecht, Michael, Prof. Dr. (Animal Physiology/Systems Neurobiology and Neural Computation)

Duration of Project: 01/2016 - 06/2021

The scientific program is focused on sensory processing and perception. Since perception is task dependent (“perception serves a purpose”), sensory processing is connected to cognitive functions (decision making, memory function, planning, and even m ...

RG 2936: Climate Change and Health in Sub-Saharan Africa (SP 09)

Grethe, Harald, Prof. Dr. (International Agricultural Trade and Development)

Duration of Project: 03/2020 - 08/2024

Computable general equilibrium models (CGEs) are used to gain an understanding of economy-wide implications of exogenous shocks to national economies such as climate, policy or world market price change. Climate change impacts on health through a var ...

RG 2841/1: A Comprehensive Repository of Regulatory Elements and Their Variations in Human Disease (SP 05)

Leser, Ulf, Prof. Dr.-Ing. (Knowledge Management in Bioinformatics)

Duration of Project: 03/2020 - 09/2023

Though the introduction of whole exome sequencing (WES) has enabled the molecular diagnosis rate for patients with rare genetic disorders to rise considerably, it has levelled at a maximum of 50%. WES is limited to the coding regions, meaning that it ...

RG 2569: Agricultural Land Markets – Efficiency and Regulation

Odening, Martin, Prof. Dr. agr. habil. (Agricultural Farm Management)

Duration of Project: 08/2020 - 07/2023

The research unit FORLand is motivated by the observation of a pronounced price surge in agricultural land markets in many parts of the world in the aftermath of the financial crisis. It has been conjectured that the high liquidity in financial marke ...

RG 2569/2: Efficiency of Agricultural Land Markets – The Role of Liquidity and Competition (SP02)

Ritter, Matthias, Prof. Dr. (Quantitative Agricultural Economics especially Applied Econometrics)

Duration of Project: 08/2020 - 07/2023

Subproject 2 investigates price formation on agricultural land markets considering the interplay of (incomplete) competition, structural change, and market liquidity. The core question is: Are observed land transactions and prices the outcome of an e ...

RG 2569/2: Efficiency of Agricultural Land Markets – The Role of Liquidity and Competition (SP 02)

Odening, Martin, Prof. Dr. agr. habil. (Agricultural Farm Management)

Duration of Project: 08/2020 - 07/2023

Subproject 2 investigates price formation on agricultural land markets considering the interplay of (incomplete) competition, structural change, and market liquidity. The core question is: Are observed land transactions and prices the outcome of an e ...

RG 2569/1: Market Integration and Border Effects in Agricultural Land Markets (SP 02)

Ritter, Matthias, Prof. Dr. (Quantitative Agricultural Economics especially Applied Econometrics)

Duration of Project: 08/2017 - 04/2022

This subproject contributes to the overall objective of the research unit by empirically studying spatial price diffusion of agricultural land markets. We borrow the notion of spatial market integration from commodity price analysis and question whet ...

RG 2569/1: Market Integration and Border Effects in Agricultural Land Markets (SP 02)

Odening, Martin, Prof. Dr. agr. habil. (Agricultural Farm Management)

Duration of Project: 08/2017 - 04/2022

This subproject contributes to the overall objective of the research unit by empirically studying spatial price diffusion of agricultural land markets. We borrow the notion of spatial market integration from commodity price analysis and question whet ...

RG 2569/1: Agricultural Land Markets – Efficiency and Regulation (SP 07)

Lakes, Tobia, Prof. Dr. (Applied GIScience)

Duration of Project: 10/2017 - 01/2021

Agricultural land markets in Germany have changed substantially in the last decade, with rapidly increasing land sales and land rental prices. As a result, the spatial configuration of agricultural land use has changed, with a trend towards a higher ...

Plested, Andrew, Prof. Ph.D. (Cellular Biophysics)

Duration of Project: 02/2021 - 01/2024

The activation of AMPA-type glutamate receptors at excitatory synapses is a fundamental event in the nervous system, essential for complex thought. The molecular mechanisms govern cation permeability in AMPA receptors (including that of the critical ...

RG 2518/1: Combining Experiment, Simulation and Machine Learning to Elucidate the Activation of Glutamate Receptor Complexes (SP 08)

Plested, Andrew, Prof. Ph.D. (Cellular Biophysics)

Duration of Project: 10/2020 - 09/2023

Markov state models (MSMs) are universal frameworks to encode the switching kinetics of biomolecular machines with multiple states. MSMs have been used to interpret the multi-state nature of experimental single-molecule recordings of ion channels and ...

RG 1346/1: Cellular and Synaptic Analysis of Rodent Social Facial Touch (SP 09)

Brecht, Michael, Prof. Dr. (Animal Physiology/Systems Neurobiology and Neural Computation)

Duration of Project: 02/2013 - 01/2016

The exquisite topographic representation of the whiskers in the barrel cortex and the fact that whiskers can be easily accessed for manipulation or stimulation has greatly contributed to the success of this model system. The quantitatively controlled ...

Progress in phenological modelling on the basis of metabolomic approaches

Chmielewski, Frank-M., Prof. Dr. rer. nat. habil. (Agriculture and Plant Cultivation)

Duration of Project: 07/2014 - 12/2017

Modelling of phenological stages, such as the flowering of fruit trees, is based on temperature sums for many decades, describing both the chilling and the forcing requirements of woody plants until the beginning of flowering. These approaches go bac ...

PROCOPE 2020 "Brain Roads. Interactive Visualization of the Brain, involving Neurosurgery"

Schäffner, Wolfgang, Prof. Dr. (Matters of Activity)

Duration of Project: 01/2020 - 12/2021

Neurosurgical practices are progressively guided by tomographic scanning technologies with increasing anatomical details, such as magnetic resonance imaging (MRI). These tomographic image technologies enable presurgical analysis and planning, as well ...

IRTG 2403/1: Main Account

Ohler, Uwe, Prof. Dr. (Systems Biology of Gene Regulation (S))

Duration of Project: 01/2019 - 06/2023

The aim of the IRTG "Dissecting and Reengineering the Regulatory Genome" is to identify and characterise regulatory processes and DNA sequences that determine the activity of gene expression in eukaryotes. The researchers in Berlin, Germany, and Durh ...

IRTG 2403/1: Dissecting and Reengineering the Regulatory Genome

Ohler, Uwe, Prof. Dr. (Systems Biology of Gene Regulation (S))

Duration of Project: 01/2019 - 06/2023

The aim of the IRTG “Dissecting and Reengineering the Regulatory Genome” is to identify and characterise regulatory processes and DNA sequences that determine the activity of gene expression in eukaryotes. The researchers in Berlin, Germany, and Durh ...

IRTG 2290/1: Crossing Boundaries: Molecular Interactions in Malaria

Matuschewski, Kai, Prof. Dr. (Molecular Parasitology)

Duration of Project: 09/2017 - 02/2022

Malaria is caused by single-celled parasites known as plasmodium, which are transmitted by the bite of the Anopheles mosquito. Some basic principles of the progress of the disease and parasite-host interactions are still not understood. The German-Au ...

Intrasurgical stimulation of the human cerebral cortex – from basic physiology to cognition

Brecht, Michael, Prof. Dr. (Animal Physiology/Systems Neurobiology and Neural Computation)

Duration of Project: 11/2017 - 12/2018

Under the supervision of Peter Vajkoczy the cortices of a large number of awake neurosurgical patients are surface stimulated in order to spare movement/speech relevant cortical tissues during surgical intervention. So far, the implications of such s ...

International Conference "Genom Editing with CRISPR", September 2019 in Berlin

Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)

Duration of Project: 07/2019 - 09/2019

The discovery of the clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins in bacteria and archaea and the successful application of such CRISPR-Cas systems as a tool for genome editing have revoluti ...

Integrated Climate Change Impact Assessment of the Coffee Sector Using a Combination of Agro-Ecological Niche Modeling and a Partial Equilibrium Model of the Agricultural Sector

Kirschke, Dieter, Prof. Dr. Dr. h. c. (Agricultural Politics)

Duration of Project: 09/2011 - 08/2014

Biophysical impact models project a highly negative direct impact of climate change on the coffee crop. As plantations have a lifespan of several decades pro-active adaptive actions must be taken now. Climate change impact assessments that intend to ...

Institutional Implications of the Expansion of the Bioeconomy

Bokelmann, Wolfgang, Prof. Dr. rer. nat. habil. (Economics of Horticultural Production)

Duration of Project: 02/2017 - 07/2019

The project identifies institutional arrangements and legal regulations which contribute to achieving public acceptance of the expansion of land use based bioeconomy. It explores innovative institutional arrangements which ensure agricultural structu ...

Insight: Neuroscientific Investigations of Knowledge Effects on Visual Perception and Awareness

Abdel Rahman, Rasha, Prof. Dr. rer. nat. (Neuralcognitive Psychology)

Duration of Project: 10/2017 - 06/2022

According to classic and current models visual perception can be viewed as encapsulated in the sense that it is not modulated by cognitive factors such as expectations or prior knowledge. Yet, evidence is cumulating that even verbally transmitted kno ...

Identification of New Candidate Genes for Insulin Sensitivity and Insulin Resistance in the Berlin Fat Mouse

Hesse-Wilting, Deike, Dr. (Breeding Biology and Molecular Animal Breeding)

Duration of Project: 09/2018 - 01/2023

Insulin resistance is the reduced responsiveness of cells and tissues to insulin and can ultimately proceed to type 2 diabetes. The aim of the proposed project is to further clarify the genetic causes for insulin resistance as well as the maintenance ...

Identification and Analysis of Genes Involved in Tetrapyrrole Metabolism and Plastid-Derived ROS-Mediated Signaling in Chlamydomonas Reinhardtii

Grimm, Bernhard, Prof. Dr. rer. nat. Prof. Dr. (Plant Physiology)

Duration of Project: 07/2019 - 07/2021

The tetrapyrrole biosynthesis (TBS) is tightly controlled at the transcriptional and the posttranslational level. Due to photooxidative stress caused by accumulating tetrapyrrole intermediates, multiple factors are required for a fine-tuned metabolic ...

Genomic Characterization and Evolutionary Dynamics of Developmental Gene Regulatory Networks of Paracentrotus lividus (Echinodermata: Echinoidea)

Garfield, David, Dr. (Junior Research Groups)

Duration of Project: 10/2019 - 09/2020

Genetic reconfigurations en route to a holoparasitic lifestyle in plants

Wicke, Susann, Prof. Dr. (Systematik Botany and Biodiversity)

Duration of Project: 09/2021 - 08/2022

Genetic Basis of the Hornwort’s Carbon-Concentrating Mechanism

Wicke, Susann, Prof. Dr. (Systematik Botany and Biodiversity)

Duration of Project: 03/2021 - 02/2024

Biophysical carbon concentrating mechanisms (CCMs) operating at the single-cell level have evolved independently in some eukaryotic algae and a single lineage of land plants, the hornworts. An essential component for an efficient biophysical CCM is a ...

Function and Stimulation of the Transient Increase of the Leaf Apoplastic pH During Exposure to Chlorine-Stress

Geilfus, Christoph-Martin, Prof. Dr. (Controlled Environment Horticulture)

Duration of Project: 07/2018 - 09/2022

The apoplast is an extracellular compartment that lies outside the plasma membrane (PM). External stress factors can influence the pH of the fluid film of the leaf apoplast. For instance, the apoplastic pH (pHapo) of field bean (Vicia faba L.) leaves ...

Functional in vivo Studies of Algal Sensory Photoreceptors

Hegemann, Peter, Prof. Dr. (Experimental Biophysics)

Duration of Project: 06/2019 - 10/2021

Channelrhodopsins, that we originally discovered in the green alga Chlamydomonas reinhardtii and described as a light-gated ion channels, revolutionized the field of neuroscience over the past decade by enabling neuroscientists to specifically activa ...

Functional and Physiological Significance of Phosphatidylethanolamine Synthesis in the Protozoan Parasite Toxoplasma Gondii

Gupta, Nishith, Dr. (Molecular Parasitology II)

Duration of Project: 06/2019 - 09/2019

FOR 2092/2: Auxiliary Factors for Chlorophyll Biosynthesis and Their Potential Contribution to the Assembly of Chlorophyll Into Chlorophyll-Binding Proteins (SP 03)

Grimm, Bernhard, Prof. Dr. rer. nat. Prof. Dr. (Plant Physiology)

Duration of Project: 11/2017 - 12/2021

Chlorophyll biosynthesis provides the essential pigments for photosynthesis in photoautotrophic organisms. While almost all enzymatic steps have been elucidated, the spatio-temporal organization of the pathway as well as its functional coupling to th ...

Field Potentials in the Auditory System

Kempter, Richard, Prof. Dr. (Computational Neuroscience)

Duration of Project: 04/2016 - 06/2020

Feldpotentiale können nicht-invasiv auf der Oberfläche des Kopfes gemessen werden. Sie können zum Beispiel durch akustische Stimuli erzeugt werden. Dieses Auditorische Hirnstammpotential hat erhebliche klinische Relevanz, aber trotzdem ist unklar, wi ...

EXIST-Founding Scholarship

Upmeier zu Belzen, Annette, Prof. Dr. (Biology Education)

Duration of Project: 01/2017 - 12/2017

App-basierte und problemorientierte Lernumgebung für das personalisierte Erwerben von Fachwissen im MINT-Bereich und von Kompetenzen der Erkenntnisgewinnung. // Das Ziel der Ausgründung ist das Angebot einer personalisierten problembasierten Lernumge ...

EXC 314/1: Unifying Systems in Catalysis (UniSysCat)

SZF-1, Leitung Servicezentrum Forschung, (Research Service Centre)

Duration of Project: 01/2019 - 12/2025

The central scientific objective of UniSysCat (Unifying Systems in Catalysis) is to master the next stage of future challenges in catalysis: how to elucidate, create, and control reaction networks in chemical and biological catalysis at different lev ...

Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)

Duration of Project: 01/2019 - 12/2022

Oxygen photosynthesis in green plants, algae and cyanobacteria is catalysed by two large membrane protein complexes Photosystem I (PSI) and Photosystem II (PSII). Both complexes contain a reaction centre (RC) that conducts a light-driven charge trans ...

EXC 2049/1: Comprehensive Approaches to Neurological and Psychiatric Disorders “NeuroCure”

SZF-1, Leitung Servicezentrum Forschung, (Research Service Centre)

Duration of Project: 01/2019 - 12/2025

Neurological and psychiatric disorders pose a massive burden to society, and our understanding of the underlying molecular and pathophysiological mechanisms is limited. In addition, translation of knowledge into clinical advances has proven difficult ...

EXC 2002/1: Science of Intelligence (SCIoI)

Pauen, Michael, Prof. Dr. (Philosophy of Spirit)

Duration of Project: 01/2019 - 12/2025

Understanding intelligence is one of the great scientific challenges of our time. Yet, in spite of extensive research efforts spanning many scientific disciplines, our understanding of intelligence remains fragmented and incomplete. The proposed Clus ...

EXC 2002/1: Object-Level Scene Descriptions and Attention in Visual Search (Research Unit 1, SP 01)

Rolfs, Martin, Prof. Dr. (General Psychology - Active Perception and Cognition)

Duration of Project: 09/2019 - 08/2022

This project focuses on the potential of object-level search processes for understanding visual scene analysis in humans and assesses their potential for real-world scene interpretation and search tasks by computer vision systems. In order to perform ...