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Analysis of Coupling Between Substrate Binding and ATP Hydrolysis in Canonical Homo- and Heterodimeric Amino Acid ABC Import Systems

Schneider, Erwin, Prof. Dr. rer. nat. (Physiology of Microorganisms)

Duration of Project: 07/2016 - 01/2021

Canonical ABC transport systems mediating the uptake of solutes in prokaryotes are composed of an extracytoplasmic solute binding protein, two pore-forming subunits and an ATPase dimer. Our current knowledge on the mechanism of Type I importers is la ...

CooC2/AcsF and Cfd1/Nbp35: Maturation of Complex Fe/S-Clusters by MinD-Type ATPases (PP 1927 – Iron/Sulfur for Life)

Dobbek, Holger, Prof. Dr. rer. nat. (Structural Biology / Biochemistry)

Duration of Project: 01/2017 - 12/2021

Anaerobic bacteria and archaea use homologous enzymes to convert CO2 and H2 to acetyl-CoA and methane, which determine since the dawn of life the global carbon cycle on earth. At first we want to investigate whether the homologous enzymes from archae ...

CRC 1078: Protonation Dynamics in Protein Function

SZF-1, Leitung Servicezentrum Forschung, (Research Service Centre)

Duration of Project: 01/2013 - 12/2020

How do proteins function? Which mechanisms are effective in the regulation of processes by proteins? These questions are addressed by molecular life-science research at the borders of biology, chemistry and physics. In doing so, key principles of pro ...

Mechanism of metal-specific ECF transporters

Eitinger, Thomas, Prof. Dr. rer. nat. (Microbiology)

Duration of Project: 04/2017 - 09/2020

Energy-coupling factor (ECF) transporters represent a large subgroup of the ATP-binding cassette (ABC) transporters and are involved in micronutrient uptake in prokaryotes. Substrates comprise water-soluble vitamins and the transition metal ions Co2+ ...

Mechanism of Ni, Fe-Containing Carbon Monoxide Dehydrogenases

Dobbek, Holger, Prof. Dr. rer. nat. (Structural Biology / Biochemistry)

Duration of Project: 07/2019 - 06/2022

Ni, Fe-containing carbon monoxide dehydrogenases (CODHs) catalyze the reversible oxidation of CO with water to CO2, two protons and 2 electrons, e.g. allowing bacteria and archaea to convert CO2 to CO, which is condensed with a methyl-cation and CoA ...

PP 1617: Phenotypic Heterogeneity and Sociobiology of Bacterial Populations

Hengge, Regine, Prof. Dr. (Microbiology)

Duration of Project: 07/2015 - 12/2019

Bakterielle Biofilme zeigen räumliche physiologische Differenzierung, die Nährstoff- und/oder Sauerstoffgradienten folgt. Fluoreszenz- und EM-Analysen von Kryoschnitten durch Makrokoloniebiofilme von E. coli zeigen eine klare Stratifizierung mit wach ...

PP 1623: Peptide-Templated Bioconjugation with Proteins on and in Living Cells for Investigations of GPCR Transport and Cross-Reactivity

Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)

Duration of Project: 02/2016 - 06/2019

The functional properties of G-protein coupled receptors (GPCRs) depend on localisation, density of surface expression and their mobility in the cell membrane. Some GPCRs undergo dynamic equilibria between monomeric and dimeric forms. Microscopic ima ...

RTG 2473/1: Bioactive Peptides – Innovative Aspects of Synthesis and Biosynthesis

Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)

Duration of Project: 04/2019 - 09/2023

The Research Training Group (RTG) “Bioactive Peptides – Innovative Aspects of Synthesis and Biosynthesis” aims to provide a structured curriculum on peptide research for doctoral students. In the past years, peptide research has become of significant ...

The functional impact of co- and post-translational N-terminal protein modifications in the chloroplast under stresses.

Grimm, Bernhard, Prof. Dr. rer. nat. Prof. Dr. (Plant Physiology)

Duration of Project: 01/2021 - 12/2023

Chloroplasts primarily function as bioreactors converting light into chemical energy. In addition, they also act as regulatory hub for intracellular communication and mediation of environmental impacts to regulate nuclear gene expression. Chloroplast ...