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Using the Sunlight for Biocyatalysis – Development of Photo-Bioelectrode-Structures for Synthesis Isolation, Stabilization, Modification and Assembly of Photosystems and Its Components in Hybrid-Assemblies for Photo-Biocatalysis

Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)

Duration of project: 08/2013 - 10/2017

The aim of the Tamdem-project is to develop light-activated electrode devices for biocatalytical purposes. Therefore photosystems or components should be combined with electrodes for an efficient photo-electron transfer. By coupling various enzyme sy ...

Usage of Solar Energy for the Bioelectrocatalysis – Photobiohybrid Eletrodes for the Light-Driven Synthesis of Valuable Substances (II, SP B)

Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)

Duration of project: 02/2018 - 01/2021

The aims of the Tandem-project are light-triggered electrodes for efficient energy conversion. In the frame of the prolonged period of work it is planned to increase the efficiency of photobio-electrodes and also to couple them with enzymatic convers ...

The functional impact of co- and post-translational N-terminal protein modifications in the chloroplast under stresses.

Grimm, Bernhard, Prof. Dr. rer. nat. Prof. Dr. (Plant Physiology)

Duration of project: 01/2021 - 12/2023

Chloroplasts primarily function as bioreactors converting light into chemical energy. In addition, they also act as regulatory hub for intracellular communication and mediation of environmental impacts to regulate nuclear gene expression. Chloroplast ...

The Centromeric Nucleosome in Yeast: Interaction With the Inner Kinetochore and Assembly by the Chaperone Yta7/ ATAD2

Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)

Duration of project: 05/2022 - 04/2025

The faithful transmission of genetic information from mother to daughter cells during mitosis requires that the sister chromatids of each chromosome are properly segregated to the daughter cells. For this, the kinetochore attaches on one side to the ...

Taking snapshots of photosynthetic water oxidation: simultaneous X-ray spectroscopy and crystallography

Zouni, Athina, Dr. (Experimental Biophysics)

Duration of project: 11/2013 - 10/2016

The objective of this project is to study the overall protein structure and dynamics, as well as the chemical structure and dynamics of the oxygen-evolving complex (OEC) of the Photosystem II membrane bound protein, that catalyses the light-driven wa ...

Singlet Molecular Oxygen and Photodynamic Effects (PDE)

Röder, Beate, Prof. Dr. rer. nat. habil. (Experimental Physics / Photobiophysics)

Duration of project: 05/2017 - 07/2017

The 2nd Chinese-German Workshop on Singlet Oxygen and Photodynamic Effects will be held on 30th March until 2nd June 2017, in Berlin the capital of Germany, which is a completely independent meeting. The aim is to provide a bilateral scientific and t ...

Single-Shot Spectrometer for Time-Resolved Simultaneous Vis- and IR Measurements

Hegemann, Peter, Prof. Dr. (Head of Department)

Duration of project: 07/2016 - 12/2019

The aim of this project is the set-up of a novel end-station at the IRIS-beamline of BESSY II for simultaneous, microsecond time-resolved infra-red- and UV/Vis-spectroscopy of non-cyclic systems. The station will be used for first experiments in the ...

RTG 2473/1: Bioactive Peptides – Innovative Aspects of Synthesis and Biosynthesis

Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)

Duration of project: 04/2019 - 09/2023

The Research Training Group (RTG) “Bioactive Peptides – Innovative Aspects of Synthesis and Biosynthesis” aims to provide a structured curriculum on peptide research for doctoral students. In the past years, peptide research has become of significant ...

RTG 2424/1: Computational Methods for Oncology: Towards Personalized Therapies in Cancer

Leser, Ulf, Prof. Dr.-Ing. (Knowledge Management in Bioinformatics)

Duration of project: 06/2019 - 11/2023

Recent advances in DNA sequencing and molecular profiling have triggered a major shift in cancer research. Traditional coarse-grained and phenomenological examinations and therapy decisions are replaced by individualized approaches that integrate mol ...

RTG 1772/2: Computational Systems Biology

Klipp, Edda, Prof. Dr. rer. nat. Dr. h.c. (Theoretical Biophysics)

Duration of project: 08/2015 - 01/2020

Biology has turned into a quantitative, information-driven science. Like physics in the first half of the twentieth century, biology now generates very challenging questions and masses of data that drive the development of theory and technology. Ther ...

RG 2841/1: A Comprehensive Repository of Regulatory Elements and Their Variations in Human Disease (SP 05)

Leser, Ulf, Prof. Dr.-Ing. (Knowledge Management in Bioinformatics)

Duration of project: 03/2020 - 09/2023

Though the introduction of whole exome sequencing (WES) has enabled the molecular diagnosis rate for patients with rare genetic disorders to rise considerably, it has levelled at a maximum of 50%. WES is limited to the coding regions, meaning that it ...

Plested, Andrew, Prof. Ph.D. (Cellular Biophysics)

Duration of project: 02/2021 - 01/2024

The activation of AMPA-type glutamate receptors at excitatory synapses is a fundamental event in the nervous system, essential for complex thought. The molecular mechanisms govern cation permeability in AMPA receptors (including that of the critical ...

RG 2518/1: Combining Experiment, Simulation and Machine Learning to Elucidate the Activation of Glutamate Receptor Complexes (SP 08)

Plested, Andrew, Prof. Ph.D. (Cellular Biophysics)

Duration of project: 10/2020 - 09/2023

Markov state models (MSMs) are universal frameworks to encode the switching kinetics of biomolecular machines with multiple states. MSMs have been used to interpret the multi-state nature of experimental single-molecule recordings of ion channels and ...

Regulation of Kinetochore Function in Yeast by Modification of the Core Region of the Centromeric Nucleosome

Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)

Duration of project: 02/2020 - 07/2023

Centromeres are the regions of the chromosome where the kinetochore is assembled, and they establish a physical link between the centromeric chromatin and the microtubule for chromosome segregation in mitosis. In Saccharomyces cerevisiae, centromeric ...

PP 1926/1: Development and Application of Novel Optogenetic Tools in Specific Intracellular Compartments

Hegemann, Peter, Prof. Dr. (Experimental Biophysics)

Duration of project: 09/2016 - 01/2019

The aim of this work is the development of novel optogenetic tools that allow investigations on subcellular compartments. In the first project, we will combine proton and chloride channels or chloride pumps with targeting motives for synaptic vesicle ...

PP 1623: Peptide-Templated Bioconjugation with Proteins on and in Living Cells for Investigations of GPCR Transport and Cross-Reactivity

Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)

Duration of project: 02/2016 - 06/2019

The functional properties of G-protein coupled receptors (GPCRs) depend on localisation, density of surface expression and their mobility in the cell membrane. Some GPCRs undergo dynamic equilibria between monomeric and dimeric forms. Microscopic ima ...

PP 1617: Phenotypic Heterogeneity and Sociobiology of Bacterial Populations

Hengge, Regine, Prof. Dr. (Microbiology)

Duration of project: 07/2015 - 12/2019

Bakterielle Biofilme zeigen räumliche physiologische Differenzierung, die Nährstoff- und/oder Sauerstoffgradienten folgt. Fluoreszenz- und EM-Analysen von Kryoschnitten durch Makrokoloniebiofilme von E. coli zeigen eine klare Stratifizierung mit wach ...

Mechanism of Ni, Fe-Containing Carbon Monoxide Dehydrogenases

Dobbek, Holger, Prof. Dr. rer. nat. (Structural Biology / Biochemistry)

Duration of project: 07/2019 - 06/2023

Ni, Fe-containing carbon monoxide dehydrogenases (CODHs) catalyze the reversible oxidation of CO with water to CO2, two protons and 2 electrons, e.g. allowing bacteria and archaea to convert CO2 to CO, which is condensed with a methyl-cation and CoA ...

Mechanism of metal-specific ECF transporters

Eitinger, Thomas, Prof. Dr. rer. nat. (Microbiology)

Duration of project: 04/2017 - 09/2020

Energy-coupling factor (ECF) transporters represent a large subgroup of the ATP-binding cassette (ABC) transporters and are involved in micronutrient uptake in prokaryotes. Substrates comprise water-soluble vitamins and the transition metal ions Co2+ ...

JRG/3: Collective Information Processing – From Individual Sensory Inputs to Swarming and Collective Decision Making

Romanczuk, Pawel, Dr. (Junior Research Groups)

Duration of project: 11/2020 - 10/2021

The main objective of the project is the development and analysis of new individual based mathematical models of collective motion, which explicitly take the sensory perception into account, as the proximate mechanism of social interactions. This app ...

JRG/2: Collective Information Processing – From Individual Sensory Inputs to Swarming and Collective Decision Making II

Romanczuk, Pawel, Dr. (Junior Research Groups)

Duration of project: 05/2019 - 08/2021

The main objective of the project is the development and analysis of new individual based mathematical models of collective motion, which explicitly take the sensory perception into account, as the proximate mechanism of social interactions. This app ...

JRG/1: Collective Information Processing – From Individual Sensory Inputs to Swarming and Collective Decision Making

Romanczuk, Pawel, Dr. (Junior Research Groups)

Duration of project: 06/2016 - 04/2021

The main objective of the project is the development and analysis of new individual based mathematical models of collective motion, which explicitly take the sensory perception into account, as the proximate mechanism of social interactions. This app ...

IRTG 2403/1: Main Account

Ohler, Uwe, Prof. Dr. (Systems Biology of Gene Regulation (S))

Duration of project: 01/2019 - 06/2023

The aim of the IRTG "Dissecting and Reengineering the Regulatory Genome" is to identify and characterise regulatory processes and DNA sequences that determine the activity of gene expression in eukaryotes. The researchers in Berlin, Germany, and Durh ...

IRTG 2403/1: Dissecting and Reengineering the Regulatory Genome

Ohler, Uwe, Prof. Dr. (Systems Biology of Gene Regulation (S))

Duration of project: 01/2019 - 06/2023

The aim of the IRTG “Dissecting and Reengineering the Regulatory Genome” is to identify and characterise regulatory processes and DNA sequences that determine the activity of gene expression in eukaryotes. The researchers in Berlin, Germany, and Durh ...

International Conference "Genom Editing with CRISPR", September 2019 in Berlin

Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)

Duration of project: 07/2019 - 09/2019

The discovery of the clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins in bacteria and archaea and the successful application of such CRISPR-Cas systems as a tool for genome editing have revoluti ...