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PP 1879: Nucleotide Second Messenger Signaling in Bacteria/Coordination Project

Hengge, Regine, Prof. Dr. (Microbiology)

Duration of project: 09/2016 - 08/2021

The overall goal of SPP 1879 over the next six years is to built a tightly collaborating and internationally radiating scientific community in the highly dynamic field of bacterial nucleotide second messenger signalling. Achieving this goal not only ...

PP 1879: Nucleotide Second Messenger Signaling in Bacteria/Coordination Fund

Hengge, Regine, Prof. Dr. (Microbiology)

Duration of project: 09/2019 - 06/2023

The DFG priority programme SPP 1879 is a research consortium studying bacterial second messenger signalling that currently funds 18 research projects at German universities and other research institutions. By including representatives of all clades o ...

PP 1784: Cellular Imaging of RNA C-to-U Editing

Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)

Duration of project: 01/2016 - 06/2019

RNA editing impacts RNA splicing and protein translation. The recent progress in high-throughput RNA sequencing has revealed an increasing number of mRNA editing sites. However, these methods provide an overview about the editing state of an ensemble ...

PP 1623: Peptide-Templated Bioconjugation with Proteins on and in Living Cells for Investigations of GPCR Transport and Cross-Reactivity

Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)

Duration of project: 02/2016 - 06/2019

The functional properties of G-protein coupled receptors (GPCRs) depend on localisation, density of surface expression and their mobility in the cell membrane. Some GPCRs undergo dynamic equilibria between monomeric and dimeric forms. Microscopic ima ...

High-Valent transition Metal reactive Intermediates in Oxidation Reactions

Ray, Kallol, Prof. Dr. (Inorganic Reaction Mechanism and Spectroscopy)

Duration of project: 01/2019 - 06/2022

DFG Research Grant: High Performance Auxiliaries for a Cysteine-Tolerant Native Chemical Ligation at Arbitrary Sites

Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)

Duration of project: 01/2018 - 12/2021

The Native Chemical Ligation (NCL) between unprotected peptide thioesters and unprotected cysteinyl peptides provides access to proteins in defined posttranslational modification states. However, the requirement for cysteine limits the scope of NCL r ...

DFG Research Grant: Energy Transfer and Enforced Intercalation – Bright and Responsive DNA-Based FIT-Probes for RNA Imaging in Live Cells

Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)

Duration of project: 09/2013 - 06/2017

Fluorogenic hybridization probes enable real-time measurements of RNA molecules and RNA transport within living wild-type cells. Powerful probes furnish significant enhancements of fluorescence emission upon binding of the RNA target. However, the br ...

DFG Research Grant: Designing Collagen-Inspired Template-[Protein]3-Hybrids: From Switchable High Molecular Weight Nanostructures Towards Processing Collageneous Materials for Cell Culture

Börner, Hans, Prof. Dr. (Organic Synthesis of Functional Systems)

Duration of project: 01/2014 - 12/2017

Objectives of the joint project are the synthesis of collagen-inspired, template-protein hybrids with high molecular weight. Switchable templates enable activation of self-assembly into anisotropic nano-objects with collageneous triple helices. The p ...

CRC 765/3: Nucleic Acid-Ligand Conjugates – Precision Tools for High Affinity and High Specificity Interactions in Chemistry and Biology (SP B01)

Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)

Duration of project: 01/2008 - 12/2019

The spatially defined display of ligands on nucleic acid architectures enables explorations of scope and specificity of multivalent binding. We will address fundamental questions about the reach and specificity of multivalency. Is there a distance li ...