Projects (26)
1/2 
-
Hackbarth, Steffen, Dr. rer. nat. (Experimental Physics / Photobiophysics)
Duration of project: 11/2018 - 06/2023
Financer: Sonstige StiftungenSubject of the planned work is the optical, time-resolved detection of singlet oxygen phosphorescence, the extremely weak emission of the central protagonist of photodynamic tumor therapy (PDT). Three subtasks are to be solved within the project.
1. ... 3rd Sino-German workshop on "Singlet molecular oxygen and photodynamic effects"
Hackbarth, Steffen, Dr. rer. nat. (Experimental Physics / Photobiophysics)
Duration of project: 02/2019 - 04/2019
Financer: DFG: SonstigesThe 3nd Chinese-German Workshop on Singlet Oxygen and Photodynamic Effects will be held on 8-13 April 2019, in Fuzhou city in Fujian Porvince, China, which is a completely independent meeting. The aim is to provide a bilateral scientific and technica ...
Analysis of Functional Brain Connections by In Vivo Optogenetics and Holography
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 11/2020 - 10/2023
Financer: DFG: SachbeihilfeThe relationship between the function and connectivity of cortical circuits has been a long-standing theme in neuroscience. Although since decades ago the predominant pathways of cortical information processing in primary sensory area have been descr ...
A Quantitative Force Map of the Mitotic Spindle
Reber, Simone, Dr. (Department of Biology)
Duration of project: 05/2018 - 07/2021
Financer: DFG: SachbeihilfeThe goal of this research proposal is to understand the way in which cells engineer micrometerscale structures. In particular, we aim to understand how different force generating systems collectively define the shape of the metaphase spindle. The bip ...
-
Müller, Peter, (Molecular Biophysics)
Duration of project: 02/2019 - 07/2022
Financer: DFG: SachbeihilfeProtein kinases are one of the biologically most important protein families which play a significant role in the regulation of nearly all physiological processes since they modulate the function of proteins. Due to this unique importance, mutation(s) ...
CRC 1078/1: Gating and Ion Transport Dynamics in Channelrhodopsin and Light-Driven Pumps (SP B02)
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 01/2013 - 12/2020
During the recent funding period, we characterised anion-conducting channelrhodopsins (ACRs) including the novel family of MerMAIDs identified by Tara Ocean metagenomics. Within this funding period, we will further study MerMAIDs and continue with th ...
CRC 1078/1: Structural Basis of Proton Release in Water Oxidation by Photosystem II (SP A05)
Zouni, Athina, (Experimental Biophysics)
Duration of project: 01/2013 - 03/2021
In oxygenic photosynthesis, water is oxidized and dioxygen is formed at the Mn4Ca complex of photosystem II (PSII), a 750 kDa protein-cofactor complex embedded in the thylakoid membrane of plants and cyanobacteria. Reliable structural models of PSII ...
CRC 1078/1: Structural Dynamics of Channelrhodopsins (SP B01)
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 01/2013 - 12/2020
The proposed project aims at an elucidation of the mechanism governing ChR gating and transport. For the understanding of protonation dynamics that occur during activation (gating) of the channel and during transport of the ions across the membrane, ...
-
Bartl, Franz, Prof. Dr. (Biophysical Chemistry)
Duration of project: 04/2017 - 12/2020
The focus in this project is on the spectroscopic investigation of different representatives of channelrhodopsins and phytochromes. The aim is to explore the photochemistry and the protonation dynamics that direct the photocycles and consequently the ...
-
Krantz, Maria, (Theoretical Biophysics)
Duration of project: 10/2019 - 12/2019
Financer: DFG: Sonderforschungsbereich - Beteiligungen -
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 07/2016 - 06/2020
Cytoplasmic increases in calcium trigger enzymatic cascades responsible for synaptic plasticity in the brain. However, to date, genetically-encoded approaches to control calcium abundance, and the cognate enzymes calcium activates, are lacking. We wi ...
Development and Modification of Chrimson for subcellular Applications
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 10/2019 - 02/2024
Financer: DFG: SachbeihilfeThe aim of the project is to further characterize and engineer Chrimson, the channelrhodopsin with the most red shifted absorption spectrum and high proton selectivity, which shares structural features both with archaeal light driven proton pumps and ...
-
Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of project: 11/2017 - 12/2018
Financer: DFG-Exzellenzinitiative: ClusterOxygen photosynthesis in green plants, algae and cyanobacteria is catalyzed by the two large membrane protein complexes Photosystem I (PSI) and Photosystem II (PSII). Both complexes contain a reaction center (RC) that conducts a light-driven charge t ...
-
Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of project: 11/2012 - 10/2017
Financer: DFG-Exzellenzinitiative: ClusterPhotosystem II (PSII) of oxygenic photosynthesis has the unique capability of utilizing visible light to oxidize water at the Mn4CaO5-cluster (the water oxidizing complex, WOC). Important progress in elucidating the molecular structure of the WOC has ...
ERC: Mechanism of Enzyme Rhodopsin Activation (MERA)
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 10/2016 - 09/2021
Channelrhodopsin which was discovered and described as a light-gated ion channel in my laboratory, has revolutionized the field of neuroscience over the past decade by enabling researchers to specifically activate selected neurons in a large ensemble ...
-
Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of project: 01/2019 - 12/2022
Oxygen photosynthesis in green plants, algae and cyanobacteria is catalysed by two large membrane protein complexes Photosystem I (PSI) and Photosystem II (PSII). Both complexes contain a reaction centre (RC) that conducts a light-driven charge trans ...
Functional in vivo Studies of Algal Sensory Photoreceptors
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 06/2019 - 10/2021
Financer: DFG: SachbeihilfeChannelrhodopsins, that we originally discovered in the green alga Chlamydomonas reinhardtii and described as a light-gated ion channels, revolutionized the field of neuroscience over the past decade by enabling neuroscientists to specifically activa ...
Mechanism of metal-specific ECF transporters
Eitinger, Thomas, Prof. Dr. rer. nat. (Microbiology)
Duration of project: 04/2017 - 09/2020
Financer: DFG: SachbeihilfeEnergy-coupling factor (ECF) transporters represent a large subgroup of the ATP-binding cassette (ABC) transporters and are involved in micronutrient uptake in prokaryotes. Substrates comprise water-soluble vitamins and the transition metal ions Co2+ ...
PP 1617: Phenotypic Heterogeneity and Sociobiology of Bacterial Populations
Hengge, Regine, Prof. Dr. (Microbiology)
Duration of project: 07/2015 - 12/2019
Financer: DFG: SachbeihilfeBakterielle Biofilme zeigen räumliche physiologische Differenzierung, die Nährstoff- und/oder Sauerstoffgradienten folgt. Fluoreszenz- und EM-Analysen von Kryoschnitten durch Makrokoloniebiofilme von E. coli zeigen eine klare Stratifizierung mit wach ...
-
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 09/2016 - 01/2019
Financer: DFG: SachbeihilfeThe aim of this work is the development of novel optogenetic tools that allow investigations on subcellular compartments. In the first project, we will combine proton and chloride channels or chloride pumps with targeting motives for synaptic vesicle ...
-
Plested, Andrew, Prof. Ph.D. (Cellular Biophysics)
Duration of project: 10/2020 - 09/2023
Financer: DFG: ForschergruppenMarkov state models (MSMs) are universal frameworks to encode the switching kinetics of biomolecular machines with multiple states. MSMs have been used to interpret the multi-state nature of experimental single-molecule recordings of ion channels and ...
Single-Shot Spectrometer for Time-Resolved Simultaneous Vis- and IR Measurements
Hegemann, Peter, Prof. Dr. (Head of Department)
Duration of project: 07/2016 - 12/2019
Financer: BMBFThe aim of this project is the set-up of a novel end-station at the IRIS-beamline of BESSY II for simultaneous, microsecond time-resolved infra-red- and UV/Vis-spectroscopy of non-cyclic systems. The station will be used for first experiments in the ...
Singlet Molecular Oxygen and Photodynamic Effects (PDE)
Röder, Beate, Prof. Dr. rer. nat. habil. (Experimental Physics / Photobiophysics)
Duration of project: 05/2017 - 07/2017
Financer: DFG: SonstigesThe 2nd Chinese-German Workshop on Singlet Oxygen and Photodynamic Effects will be held on 30th March until 2nd June 2017, in Berlin the capital of Germany, which is a completely independent meeting. The aim is to provide a bilateral scientific and t ...
-
Zouni, Athina, Dr. (Experimental Biophysics)
Duration of project: 11/2013 - 10/2016
Financer: Sonstige internationale öffentliche MittelgeberThe objective of this project is to study the overall protein structure and dynamics, as well as the chemical structure and dynamics of the oxygen-evolving complex (OEC) of the Photosystem II membrane bound protein, that catalyses the light-driven wa ...
-
Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of project: 02/2018 - 01/2021
Financer: BMBFThe aims of the Tandem-project are light-triggered electrodes for efficient energy conversion. In the frame of the prolonged period of work it is planned to increase the efficiency of photobio-electrodes and also to couple them with enzymatic convers ...
