Area
Projects (65)
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Hackbarth, Steffen, Dr. rer. nat. (Experimental Physics / Photobiophysics)
Duration of project: 11/2018 - 06/2023
Financer: Sonstige StiftungenSubject of the planned work is the optical, time-resolved detection of singlet oxygen phosphorescence, the extremely weak emission of the central protagonist of photodynamic tumor therapy (PDT). Three subtasks are to be solved within the project.
1. ... 3rd Sino-German workshop on "Singlet molecular oxygen and photodynamic effects"
Hackbarth, Steffen, Dr. rer. nat. (Experimental Physics / Photobiophysics)
Duration of project: 02/2019 - 04/2019
Financer: DFG: SonstigesThe 3nd Chinese-German Workshop on Singlet Oxygen and Photodynamic Effects will be held on 8-13 April 2019, in Fuzhou city in Fujian Porvince, China, which is a completely independent meeting. The aim is to provide a bilateral scientific and technica ...
Advanced Lecture Course in Systems Biology
Klipp, Edda, Prof. Dr. rer. nat. Dr. h.c. (Theoretical Biophysics)
Duration of project: 02/2018 - 07/2018
Financer: Sonstige StiftungenThe aim of the Advanced Lecture Course on Systems Biology is to bring in contact young researchers from different areas to the field of systems biology. Around 30 teachers present their knowledge to around 120 predocs and young scientists in talks, p ...
Advanced Lecture Course in Systems Biology 2020
Klipp, Edda, Prof. Dr. rer. nat. Dr. h.c. (Theoretical Biophysics)
Duration of project: 03/2020 - 03/2020
Financer: StiftungDer Advanced Lecture Course in Systems Biology hat zum Ziel, jungen Forschern aus unterschiedlichen Fachgebieten das Feld der Systembiologie näer zu bringen. Ca 30 Lehrende präsentieren ihr Wissen ca. 120 Doktoranden und Doktorandinnen sowie jungen W ...
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Schneider, Erwin, Prof. Dr. rer. nat. (Physiology of Microorganisms)
Duration of project: 07/2016 - 01/2021
Financer: DFG: SachbeihilfeCanonical ABC transport systems mediating the uptake of solutes in prokaryotes are composed of an extracytoplasmic solute binding protein, two pore-forming subunits and an ATPase dimer. Our current knowledge on the mechanism of Type I importers is la ...
Analysis of Functional Brain Connections by In Vivo Optogenetics and Holography
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 11/2020 - 10/2023
Financer: DFG: SachbeihilfeThe relationship between the function and connectivity of cortical circuits has been a long-standing theme in neuroscience. Although since decades ago the predominant pathways of cortical information processing in primary sensory area have been descr ...
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Kshirsagar, Rucha, Dr. Ph.D. (Molecular Cell Biology)
Duration of project: 10/2018 - 07/2023
Financer: DFG: Eigene Stelle (Sachbeihilfe) ANIMATION – designing movement
Schäffner, Wolfgang, Prof. Dr. phil. (Knowledge and Cultural History)
Duration of project: 07/2016 - 12/2016
Financer: Einstein Stiftung BerlinThe kick-off event "ANIMATION - designing movement", supported by the Einstein Foundation Berlin, brought together the science illustrators Amir Andikfar and Jonas Lauströer, the biologist John A. Nyakatura and the animation designer Nicolas Deveaux ...
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Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)
Duration of project: 09/2019 - 09/2019
Financer: DFG: SonstigesThe discovery of the clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins in bacteria and archaea and the successful application of such CRISPR-Cas systems as a tool for genome editing have revoluti ...
A Quantitative Force Map of the Mitotic Spindle
Reber, Simone, Dr. (Department of Biology)
Duration of project: 05/2018 - 07/2021
Financer: DFG: SachbeihilfeThe goal of this research proposal is to understand the way in which cells engineer micrometerscale structures. In particular, we aim to understand how different force generating systems collectively define the shape of the metaphase spindle. The bip ...
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Müller, Peter, (Molecular Biophysics)
Duration of project: 02/2019 - 07/2022
Financer: DFG: SachbeihilfeProtein kinases are one of the biologically most important protein families which play a significant role in the regulation of nearly all physiological processes since they modulate the function of proteins. Due to this unique importance, mutation(s) ...
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Dobbek, Holger, Prof. Dr. rer. nat. (Structural Biology / Biochemistry)
Duration of project: 01/2017 - 12/2021
Financer: DFG - SchwerpunktprogrammeAnaerobic bacteria and archaea use homologous enzymes to convert CO2 and H2 to acetyl-CoA and methane, which determine since the dawn of life the global carbon cycle on earth. At first we want to investigate whether the homologous enzymes from archae ...
CRC 1078/1: Gating and Ion Transport Dynamics in Channelrhodopsin and Light-Driven Pumps (SP B02)
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 01/2013 - 12/2020
During the recent funding period, we characterised anion-conducting channelrhodopsins (ACRs) including the novel family of MerMAIDs identified by Tara Ocean metagenomics. Within this funding period, we will further study MerMAIDs and continue with th ...
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Dobbek, Holger, Prof. Dr. rer. nat. (Structural Biology / Biochemistry)
Duration of project: 01/2013 - 12/2020
In oxygenic photosynthesis, water is oxidised and dioxygen is formed at the Mn4Ca complex of Photosystem II (PSII). The last ten years have seen a constant refinement of the structural details of PSII, which now provide a solid basis for further work ...
CRC 1078/1: Structural Basis of Proton Release in Water Oxidation by Photosystem II (SP A05)
Zouni, Athina, (Experimental Biophysics)
Duration of project: 01/2013 - 03/2021
In oxygenic photosynthesis, water is oxidized and dioxygen is formed at the Mn4Ca complex of photosystem II (PSII), a 750 kDa protein-cofactor complex embedded in the thylakoid membrane of plants and cyanobacteria. Reliable structural models of PSII ...
CRC 1078/1: Structural Dynamics of Channelrhodopsins (SP B01)
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 01/2013 - 12/2020
The proposed project aims at an elucidation of the mechanism governing ChR gating and transport. For the understanding of protonation dynamics that occur during activation (gating) of the channel and during transport of the ions across the membrane, ...
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Bartl, Franz, Prof. Dr. (Biophysical Chemistry)
Duration of project: 04/2017 - 12/2020
The focus in this project is on the spectroscopic investigation of different representatives of channelrhodopsins and phytochromes. The aim is to explore the photochemistry and the protonation dynamics that direct the photocycles and consequently the ...
CRC 1078: Protonation Dynamics in Protein Function
SZF-1, Leitung Servicezentrum Forschung, (Research Service Centre)
Duration of project: 01/2013 - 12/2020
Financer: DFG: SonderforschungsbereichHow do proteins function? Which mechanisms are effective in the regulation of processes by proteins? These questions are addressed by molecular life-science research at the borders of biology, chemistry and physics. In doing so, key principles of pro ...
CRC 1404/1: Adapting Genomic Data Analysis Workflows for Different Data Access Patterns (SP A02)
Leser, Ulf, Prof. Dr.-Ing. (Knowledge Management in Bioinformatics)
Duration of project: 07/2020 - 06/2024
Financer: DFG: SonderforschungsbereichDAW runtime in distributed infrastructures if often dominated by the time required for data access and data exchange (DADE), which in turn depends on the data being analysed, the tasks being executed, and the infrastructure on which a DAW runs. Chang ...
CRC 1404/1: Data Analysis Workflows for Interactive Scientific Exploration (SP A06)
Weidlich, Matthias, Prof. Dr. (Data Bases and Information Systems)
Duration of project: 07/2020 - 06/2024
Financer: DFG: SonderforschungsbereichDAWs for scientific discoveries are often exploratory. Furthermore, also the process of specifying a DAW is exploratory, involving the repeated adaptation of the current DAW specification based on results of previous executions or based on refined re ...
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Krantz, Maria, (Theoretical Biophysics)
Duration of project: 10/2019 - 12/2019
Financer: DFG: Sonderforschungsbereich - Beteiligungen -
Ohler, Uwe, Prof. Dr. (Systems Biology of Gene Regulation (S))
Duration of project: 07/2016 - 06/2021
Deep sequencing and other –omics approaches contribute significant data towards our understanding of how acclimation processes play out at different levels of gene regulation. To integrate these data, we will develop a hierarchical model for translat ...
CRC-TRR 175/1: Subcellular Modelling of Metabolic Acclimation (SP D03)
Klipp, Edda, Prof. Dr. rer. nat. Dr. h.c. (Theoretical Biophysics)
Duration of project: 07/2016 - 12/2020
Plant cold acclimation represents a multigenic process which also involves significant subcellular reallocation of primary and secondary metabolites. We will apply a sophisticated combination of subcellular omics analysis, enzyme activity measurement ...
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Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 07/2016 - 06/2020
Cytoplasmic increases in calcium trigger enzymatic cascades responsible for synaptic plasticity in the brain. However, to date, genetically-encoded approaches to control calcium abundance, and the cognate enzymes calcium activates, are lacking. We wi ...
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Erhardt, Marc, Prof. Dr. (Molecular Microbiology)
Duration of project: 01/2020 - 12/2024
Financer: Volkswagen-Stiftung (VW)Cell decision-making is the process of cells changing their phenotype according to their intrinsic programming and in response to the microenvironmental cues. Currently, little is known about the principles dictating cell decision-making in multicell ...
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Fröbisch, Nadia, Prof. Dr. (Development and Evolution)
Duration of project: 01/2019 - 12/2020
Financer: DAADAn understanding of the mechanisms underlying the regenerative programs of limb/fin and tail regeneration in vertebrates are for obvious reasons of great interest and a major research focus of the fields of molecular biology and regenerative medicine ...
Detection and functional characterization of queuosine and m5C modification in RNA
Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)
Duration of project: 11/2018 - 04/2022
Financer: DFG: SachbeihilfetRNAs are subject to a variety of chemical modifications that modulate their function in translation. In this project, we have investigated two such modifications, queuosine (Q) and cytosine-5 methylation (m5C). Our earlier work in Schizosaccharomyce ...
Development and Modification of Chrimson for subcellular Applications
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 10/2019 - 02/2024
Financer: DFG: SachbeihilfeThe aim of the project is to further characterize and engineer Chrimson, the channelrhodopsin with the most red shifted absorption spectrum and high proton selectivity, which shares structural features both with archaeal light driven proton pumps and ...
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Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of project: 11/2017 - 12/2018
Financer: DFG-Exzellenzinitiative: ClusterOxygen photosynthesis in green plants, algae and cyanobacteria is catalyzed by the two large membrane protein complexes Photosystem I (PSI) and Photosystem II (PSII). Both complexes contain a reaction center (RC) that conducts a light-driven charge t ...
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Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of project: 11/2012 - 10/2017
Financer: DFG-Exzellenzinitiative: ClusterPhotosystem II (PSII) of oxygenic photosynthesis has the unique capability of utilizing visible light to oxidize water at the Mn4CaO5-cluster (the water oxidizing complex, WOC). Important progress in elucidating the molecular structure of the WOC has ...
ERC: Mechanism of Enzyme Rhodopsin Activation (MERA)
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 10/2016 - 09/2021
Channelrhodopsin which was discovered and described as a light-gated ion channel in my laboratory, has revolutionized the field of neuroscience over the past decade by enabling researchers to specifically activate selected neurons in a large ensemble ...
Establishment of Global Histone Acetylation Patterns by HAT Complex SAS-I in S. cerevisiae
Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)
Duration of project: 08/2013 - 07/2014
Financer: DFG: SachbeihilfeEukaryotic organisms require sophisticated mechanisms to ensure that gene expression in their genome is carried out in the correct temporal and spatial manner. Posttranslational histone modifications are one mechanism by which gene expression is cont ...
Event: The Future of Theoretical Biology
Schreiber, Susanne, Prof. Dr. rer. nat. (Computational Neurophysiology)
Duration of project: 05/2017 - 12/2017
Financer: DFG: SonstigesInternational Symposium on current topics in and the future of Theoretical Biology.
EXC 1027: Image Knowledge Gestaltung. An Interdisciplinary Laboratory
Schäffner, Wolfgang, Prof. Dr. phil. (Knowledge and Cultural History)
Duration of project: 11/2017 - 12/2018
Financer: DFG-Exzellenzinitiative: ClusterDriven by the vision that “Gestaltung” is a fundamental mode of knowledge production, the Cluster
of Excellence “Image Knowledge Gestaltung. An Interdisciplinary Laboratory” developed a novel
form of interdisciplinary research. Initiated by humanit ...EXC 1027: Image Knowledge Gestaltung. An Interdisciplinary Laboratory
Schäffner, Wolfgang, Prof. Dr. phil. (Knowledge and Cultural History)
Duration of project: 11/2012 - 10/2017
Financer: DFG-Exzellenzinitiative: ClusterDriven by the vision that Gestaltung is a fundamental mode of knowledge production, the Cluster of Excellence Image Knowledge Gestaltung. An Interdisciplinary Laboratory developed a novel form of interdisciplinary research. Initiated by humanities sc ...
EXC 2049/1: Comprehensive Approaches to Neurological and Psychiatric Disorders “NeuroCure”
SZF-1, Leitung Servicezentrum Forschung, (Research Service Centre)
Duration of project: 01/2019 - 12/2025
Financer: DFG Exzellenzstrategie: ClusterNeurological and psychiatric disorders pose a massive burden to society, and our understanding of the underlying molecular and pathophysiological mechanisms is limited. In addition, translation of knowledge into clinical advances has proven difficult ...
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Zouni, Athina, PD Dr. (Honorary Chairs / Professors by Special Appointment / Part-Time Lecturers)
Duration of project: 01/2019 - 12/2022
Oxygen photosynthesis in green plants, algae and cyanobacteria is catalysed by two large membrane protein complexes Photosystem I (PSI) and Photosystem II (PSII). Both complexes contain a reaction centre (RC) that conducts a light-driven charge trans ...
EXC 314/1: Unifying Systems in Catalysis (UniSysCat)
SZF-1, Leitung Servicezentrum Forschung, (Research Service Centre)
Duration of project: 01/2019 - 12/2025
Financer: DFG Exzellenzstrategie: ClusterThe central scientific objective of UniSysCat (Unifying Systems in Catalysis) is to master the next stage of future challenges in catalysis: how to elucidate, create, and control reaction networks in chemical and biological catalysis at different lev ...
Functional in vivo Studies of Algal Sensory Photoreceptors
Hegemann, Peter, Prof. Dr. (Experimental Biophysics)
Duration of project: 06/2019 - 10/2021
Financer: DFG: SachbeihilfeChannelrhodopsins, that we originally discovered in the green alga Chlamydomonas reinhardtii and described as a light-gated ion channels, revolutionized the field of neuroscience over the past decade by enabling neuroscientists to specifically activa ...
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Garfield, David, Dr. (Junior Research Groups)
Duration of project: 10/2019 - 09/2020
Financer: DAADMutations impacting DNA regulatory elements make a disproportionate contribution to evolutionary processes and are important contributors to inter-individual variation in disease susceptibility.
We are, however, limited in our ability to predict *w ... International Conference "Genom Editing with CRISPR", September 2019 in Berlin
Ehrenhofer-Murray, Ann, Prof. Dr. (Molecular Cell Biology)
Duration of project: 07/2019 - 09/2019
Financer: Sonstige StiftungenThe discovery of the clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins in bacteria and archaea and the successful application of such CRISPR-Cas systems as a tool for genome editing have revoluti ...
IRTG 2403/1: Dissecting and Reengineering the Regulatory Genome
Ohler, Uwe, Prof. Dr. (Systems Biology of Gene Regulation (S))
Duration of project: 01/2019 - 06/2023
Financer: DFG: GraduiertenkollegsThe aim of the IRTG “Dissecting and Reengineering the Regulatory Genome” is to identify and characterise regulatory processes and DNA sequences that determine the activity of gene expression in eukaryotes. The researchers in Berlin, Germany, and Durh ...
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Ohler, Uwe, Prof. Dr. (Systems Biology of Gene Regulation (S))
Duration of project: 01/2019 - 06/2023
Financer: DFG: GraduiertenkollegsThe aim of the IRTG "Dissecting and Reengineering the Regulatory Genome" is to identify and characterise regulatory processes and DNA sequences that determine the activity of gene expression in eukaryotes. The researchers in Berlin, Germany, and Durh ...
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Romanczuk, Pawel, Dr. (Junior Research Groups)
Duration of project: 06/2016 - 04/2021
Financer: DFG: NachwuchsgruppeThe main objective of the project is the development and analysis of new individual based mathematical models of collective motion, which explicitly take the sensory perception into account, as the proximate mechanism of social interactions. This app ...
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Romanczuk, Pawel, Dr. (Junior Research Groups)
Duration of project: 05/2019 - 08/2021
Financer: DFG: NachwuchsgruppeThe main objective of the project is the development and analysis of new individual based mathematical models of collective motion, which explicitly take the sensory perception into account, as the proximate mechanism of social interactions. This app ...
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Romanczuk, Pawel, Dr. (Junior Research Groups)
Duration of project: 11/2020 - 10/2021
Financer: DFG: NachwuchsgruppeThe main objective of the project is the development and analysis of new individual based mathematical models of collective motion, which explicitly take the sensory perception into account, as the proximate mechanism of social interactions. This app ...
Mechanism of metal-specific ECF transporters
Eitinger, Thomas, Prof. Dr. rer. nat. (Microbiology)
Duration of project: 04/2017 - 09/2020
Financer: DFG: SachbeihilfeEnergy-coupling factor (ECF) transporters represent a large subgroup of the ATP-binding cassette (ABC) transporters and are involved in micronutrient uptake in prokaryotes. Substrates comprise water-soluble vitamins and the transition metal ions Co2+ ...
Mechanism of Ni, Fe-Containing Carbon Monoxide Dehydrogenases
Dobbek, Holger, Prof. Dr. rer. nat. (Structural Biology / Biochemistry)
Duration of project: 07/2019 - 06/2023
Financer: DFG: SachbeihilfeNi, Fe-containing carbon monoxide dehydrogenases (CODHs) catalyze the reversible oxidation of CO with water to CO2, two protons and 2 electrons, e.g. allowing bacteria and archaea to convert CO2 to CO, which is condensed with a methyl-cation and CoA ...
PP 1617: Phenotypic Heterogeneity and Sociobiology of Bacterial Populations
Hengge, Regine, Prof. Dr. (Microbiology)
Duration of project: 07/2015 - 12/2019
Financer: DFG: SachbeihilfeBakterielle Biofilme zeigen räumliche physiologische Differenzierung, die Nährstoff- und/oder Sauerstoffgradienten folgt. Fluoreszenz- und EM-Analysen von Kryoschnitten durch Makrokoloniebiofilme von E. coli zeigen eine klare Stratifizierung mit wach ...
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Seitz, Oliver, Prof. Dr. rer. nat. (Organic and Bioorganic Chemistry III)
Duration of project: 02/2016 - 06/2019
Financer: DFG: SachbeihilfeThe functional properties of G-protein coupled receptors (GPCRs) depend on localisation, density of surface expression and their mobility in the cell membrane. Some GPCRs undergo dynamic equilibria between monomeric and dimeric forms. Microscopic ima ...
