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Sommerschule Benin „Politikanalyse für Agrar- und Ernährungssysteme“

Grethe, Harald, Prof. Dr. (International Agricultural Trade and Development)

Duration of project: 01/2018 - 12/2018

Analysis of the interaction between Kinetochor and centrometric Chromatin in Saccharomyces cerevisiae

Kshirsagar, Rucha, Dr. Ph.D. (Molecular Cell Biology)

Duration of project: 10/2018 - 07/2023

A new approach to Pig Husbandry: reduced emissions, no tail-docking, no castration, no crates: effects onanimal health, behaviour, farmer`s satisfaction and environment

Hillmann, Edna, Prof. Dr. (Animal Husbandry and Ethology)

Duration of project: 12/2021 - 11/2024

CRC 1078/1: Gating and Ion Transport Dynamics in Channelrhodopsin and Light-Driven Pumps (SP B02)

Hegemann, Peter, Prof. Dr. (Experimental Biophysics)

Duration of project: 01/2013 - 12/2020

During the recent funding period, we characterised anion-conducting channelrhodopsins (ACRs) including the novel family of MerMAIDs identified by Tara Ocean metagenomics. Within this funding period, we will further study MerMAIDs and continue with th ...

CRC 1078/1: Structural Basis of Proton Release in Water Oxidation by Photosystem II: Crystallization, X-Ray and Neutron Diffraction Analysis of Chloride-Modified and Site-Directed Variants (SP A05)

Dobbek, Holger, Prof. Dr. rer. nat. (Structural Biology / Biochemistry)

Duration of project: 01/2013 - 12/2020

In oxygenic photosynthesis, water is oxidised and dioxygen is formed at the Mn4Ca complex of Photosystem II (PSII). The last ten years have seen a constant refinement of the structural details of PSII, which now provide a solid basis for further work ...

CRC 1078/1: Structural Basis of Proton Release in Water Oxidation by Photosystem II (SP A05)

Zouni, Athina, (Experimental Biophysics)

Duration of project: 01/2013 - 03/2021

In oxygenic photosynthesis, water is oxidized and dioxygen is formed at the Mn4Ca complex of photosystem II (PSII), a 750 kDa protein-cofactor complex embedded in the thylakoid membrane of plants and cyanobacteria. Reliable structural models of PSII ...

CRC 1078/1: Structural Dynamics of Channelrhodopsins (SP B01)

Hegemann, Peter, Prof. Dr. (Experimental Biophysics)

Duration of project: 01/2013 - 12/2020

The proposed project aims at an elucidation of the mechanism governing ChR gating and transport. For the understanding of protonation dynamics that occur during activation (gating) of the channel and during transport of the ions across the membrane, ...

CRC 1078/2: Spectroscopic Investigations of Proton Transfer Processes and Hydrogenbonded Networks in Phytochromes and Channelrhodopsins (SP B05)

Bartl, Franz, Prof. Dr. (Biophysical Chemistry)

Duration of project: 04/2017 - 12/2020

The focus in this project is on the spectroscopic investigation of different representatives of channelrhodopsins and phytochromes. The aim is to explore the photochemistry and the protonation dynamics that direct the photocycles and consequently the ...

CRC 1078: Protonation Dynamics in Protein Function

SZF-1, Leitung Servicezentrum Forschung, (Research Service Centre)

Duration of project: 01/2013 - 12/2020

How do proteins function? Which mechanisms are effective in the regulation of processes by proteins? These questions are addressed by molecular life-science research at the borders of biology, chemistry and physics. In doing so, key principles of pro ...

CRC 1315/1: Central Tasks (SP Z)

Larkum, Matthew, Prof. Dr. (Neuronal Plasticity)

Duration of project: 07/2018 - 06/2022

The brain transforms neural representations to build a new framework of prior experiences, and then maintains these representations over time. This evolution of brain states is what we refer to as memory consolidation. At present, no consensus exists ...

CRC 1315/1: Control of Memory Engram-Related Activity in the Hippocampus: Focus on Disinhibition (SP A01)

Kempter, Richard, Prof. Dr. (Computational Neuroscience)

Duration of project: 07/2018 - 06/2022

Hippocampal sharp wave/ripple complexes (SWRs, Buzsaki, 1989) are short (50-100 ms) episodes of coordinated network activity arising in the hippocampal CA3 area. They may mediate the consolidation of explicit memories, and their disruption interferes ...

CRC 1315/1: Development of Molecular Tools for Manipulating and Studying Memory Engrams (SP C01)

Hegemann, Peter, Prof. Dr. (Experimental Biophysics)

Duration of project: 07/2018 - 06/2022

Over the last decade the number, variety and specificity of optical and genetic tools that report or modify neural activity, such as calcium and voltage sensors or light-gated channels and light driven pumps, has increased exponentially. Many if not ...

CRC 1315/1: Experimental Behavior Technologies and Animal Training (SP C02)

Winter, York, Prof. Dr. (Cognitive Neurobiology)

Duration of project: 07/2018 - 06/2022

The “Experimental Behavior Technologies and Animal Training” service project provides the mechanism and resources for producing state-of-the-art behavioral systems. It will make automated methods for experimental learning and memory testing available ...

CRC 1315/1: Formation and Consolidation of Social Memories in the Ventral Hippocampus (SP A03)

Brecht, Michael, Prof. Dr. (Animal Physiology/Systems Neurobiology and Neural Computation)

Duration of project: 07/2018 - 06/2022

Animals exhibit a range of social interactions (dominance hierarchies, mating and parental behaviours) that rely on their ability to recognize conspecifics. It has been shown that the hippocampus is involved in the higher order representation of soci ...

CRC 1315/1: Mechanisms and Disturbances in Memory Consolidation: From Synapses to Systems

Larkum, Matthew, Prof. Dr. (Neuronal Plasticity)

Duration of project: 07/2018 - 06/2022

The brain transforms neural representations to build a new framework of prior experiences, and then maintains these representations over time. This evolution of brain states is what we refer to as memory consolidation. At present, no consensus exists ...

CRC 1315/1: Memory Formation and Consolidation in Defined Neurons of the Cortex (SP A04)

Larkum, Matthew, Prof. Dr. (Neuronal Plasticity)

Duration of project: 07/2018 - 06/2022

The hippocampus and related structures (entorhinal cortex [EC], perirhinal cortex [PRh], etc.) play a vital role in transforming experience into long-term memories that are then stored in the cortex, however the cellular mechanisms that designate sin ...

CRC 1315/1: Uncovering a Role for Inhibition in Tutor-Song Memory Consolidation in the Zebra Finch (SP A06)

Schreiber, Susanne, Prof. Dr. rer. nat. (Computational Neurophysiology)

Duration of project: 07/2018 - 06/2022

During development, plastic synapses enable a neuronal circuit to form a memory, but how these malleable synaptic connections allow for a durable representation on longer timescales is still a matter of debate. While the consolidation of memories is ...

CRC 1404/1: Adapting Genomic Data Analysis Workflows for Different Data Access Patterns (SP A02)

Leser, Ulf, Prof. Dr.-Ing. (Knowledge Management in Bioinformatics)

Duration of project: 07/2020 - 06/2024

DAW runtime in distributed infrastructures if often dominated by the time required for data access and data exchange (DADE), which in turn depends on the data being analysed, the tasks being executed, and the infrastructure on which a DAW runs. Chang ...

CRC 1404/1: Data Analysis Workflows for Interactive Scientific Exploration (SP A06)

Weidlich, Matthias, Prof. Dr. (Data Bases and Information Systems)

Duration of project: 07/2020 - 06/2024

DAWs for scientific discoveries are often exploratory. Furthermore, also the process of specifying a DAW is exploratory, involving the repeated adaptation of the current DAW specification based on results of previous executions or based on refined re ...

CRC 1404/1: FONDA – Foundations of Workflows for Large-Scale Scientific Data Analysis

Leser, Ulf, Prof. Dr.-Ing. (Knowledge Management in Bioinformatics)

Duration of project: 07/2020 - 06/2024

The examination of many contemporary questions in the natural sciences involves the analysis of large volumes of data using automatic analysis tools, with the interaction between them being determined in what are known as data analysis workflows. The ...

CRC 1404/1: FONDA – Foundations of Workflows for Large-Scale Scientific Data Analysis (Main Project)

Leser, Ulf, Prof. Dr.-Ing. (Knowledge Management in Bioinformatics)

Duration of project: 07/2020 - 06/2024

Essentially all scientific disciplines are generating an ever-increasing amount of data. To derive scientific discoveries, these data sets are analysed by complex data analysis workflows (DAWs), which are series of discrete analysis programs arranged ...

CRC-TRR 175/1: Chloropast Ribonucleoproteins – Stabilizing Chloroplast RNA Pools During Acclimation Responses (SP A02)

Schmitz-Linneweber, Christian, Prof. Dr. (Genetics)

Duration of project: 07/2016 - 12/2020

Chloroplast ribonucleoproteins (cpRNPs) are light-and temperature-regulated phosphoproteins. We have recently demonstrated that cpRNPs impact chloroplast mRNA accumulation and processing under low temperature conditions on an organelle-wide scale. We ...

CRC-TRR 175/1: Chloroplast RNA Polymerase Activity During Acclimation (SP A01)

Kühn, Kristina, Prof. Dr. (Molecular Cell Biology of Plant)

Duration of project: 07/2016 - 06/2020

This project aims to quantify transcriptional alterations that occur in chloroplasts during acclimation to changes in light or temperature. It will apply chloroplast nascent transcript sequencing strategies (GRO-seq and 5’-GRO-seq) in order to global ...

CRC/TRR 175/1: Exploring Possibilities of Embedding Chlamydomonas Dry Mass Into Concrete and Other Building Materials to Create a Carbon Dioxid Trap – Mini-Project

Krantz, Maria, (Theoretical Biophysics)

Duration of project: 10/2019 - 12/2019

CRC/TRR 175/1: Leveraging Deep Sequenzing Data to Move From Predictive to Mechanistic Models of Plastid Gene Expression (SP D01)

Ohler, Uwe, Prof. Dr. (Systems Biology of Gene Regulation (S))

Duration of project: 07/2016 - 06/2021

Deep sequencing and other –omics approaches contribute significant data towards our understanding of how acclimation processes play out at different levels of gene regulation. To integrate these data, we will develop a hierarchical model for translat ...