Beyond the Standard Balanced Network: Multiple Timescales in Cortical Dynamics

The balance hypothesis was designed to explain the temporal irregularity of cortical activity. However, in its current form, the theory underpinning this hypothesis, dubbed the standard model (SM) cannot explain activity fluctuations observed in the 10-200ms range. This collaborative and interdisciplinary proposal aims to extend the SM to account for these fluctuations. It will incorporate three currently neglected features: cellular heterogeneity, interactions due to finite network size and network connectivity motifs. The project investigates whatever these three neglected features may lead to activity fluctuations beyond membrane dynamics and questions their implications on the balance condition. Moreover, the fluctuations observed in the 10-200ms range play a vital role in motor control and may have direct behavioral consequences as many voluntary movements require modulation of cortical activity in this time range. Therefore, on the experimental part, we focus on the implications of these slow modulations in cortical level of the motor system in primates. We will draw on methods from statistical mechanics and non-linear dynamics to develop analytical and numerical approaches to these questions as well as on in vivo experiments to constrain the theory and test its predictions.

Principal Investigators
Farkhooi, Farzad Dr. (Details) (Computational Neurophysiology)

Duration of Project
Start date: 04/2019
End date: 09/2020

Last updated on 2021-16-12 at 19:30