EU: A New Generation of Microbial Expression Hosts and Tools for the Production of Biotherapeutics and High-Value Enzymes (SECRETERS)

The challenge addressed in the SECRETERS programme is to markedly enhance the EU’s capacity for the production of secreted high-quality recombinant proteins, with a special emphasis on therapeutic proteins (biotherapeutics) and industrial enzymes that are difficult to express. The combined markets are in excess of $140 billion p.a., and the products are of massive significance for healthcare and a sustainable bio-based economy. SECRETERS will address some of the most urgent outstanding problems associated with these industries.

(1) We will develop powerful new microbial platforms that can produce disulphide-bonded proteins in unusually high quantities and in unparalleled quality. Of the top-selling 15 recombinant proteins in recent years, over 95% were disulphide-bonded proteins , yet their production continues to be a major problem. This consortium will bring to market a suite of super-producing platforms that bypass long-standing problems in this industry, and which can handle the enormous range of disulphide-bonded new-format biotherapeutics that are emerging.
(2) A comprehensive training programme will equip SECRETERS ESRs with the interdisciplinary and intersectoral skills required to succeed in these industries. The programme addresses, head-on, the challenge that the majority of European PhD graduates do not choose a career that is even science-related, let alone research- or biotechnologically-oriented (e.g. ). A structured training plan, carried out in full accordance with the current EC Responsible Research and Innovation priorities , will provide the depth and breadth of training needed for ESRs to excel in the biotechnology industry.
(3) The project will raise the profile of the European biotechnology industry through a wide-ranging dissemination and outreach programme. Many people do not appreciate what a 'biotherapeutic' even is, or how powerful they can be, and there is equally poor appreciation of the importance of industrial enzymes in our daily lives. We will bridge a communication gap that is preventing the importance of the biotechnology industry from being fully appreciated within the EU.

Principal investigators
Klipp, Edda Prof. Dr. rer. nat. Dr. h.c. (Details) (Theoretical Biophysics)

Europäische Union (EU) - HU als Beteiligte

Duration of project
Start date: 01/2019
End date: 06/2023

Research Areas
Life Sciences, Metabolism, Biochemistry and Genetics of Microorganisms, Microbiology, Virology and Immunology

Research Areas

Last updated on 2022-22-09 at 07:05