Cellular Mechanisms of Predictive Processing and Its Effects on Perception

Predictive processing is a leading theory of brain function. However, despite several conjectures it is unknown how
predictive processing is implemented at the neural level. We will try to understand the exact role of the computations
of the layer 5 pyramidal (L5p) cells within the framework of predictive processing. The experimental paradigm
and the computational model used here are designed to answer, whether L5p cells carry predictions, as the theory
of predictive processing suggests, or are they responsible for some other computation. To this end we will a) adapt
experimental paradigms used with humans to study probabilistic computations in the mouse model, b) measure the
dendritic input and somatic output of L5p cells in mice, c) capture this activity with computational models and d)
manipulate the apical dendritic input and somatic output of L5p through noradrenaline antagonists. The project allows
us to understand the mechanisms underlying predictions and their effect on perception.

Principal Investigators
Larkum, Matthew Prof. Dr. (Details) (Neuronal Plasticity)

participating organizational facilities of the HU

Duration of Project
Start date: 09/2018
End date: 08/2020

Last updated on 2020-06-11 at 20:17