Anti-biofilm compounds from natural sources


Bacteria in biofilms are highly resistant against antibiotics, disinfectants and the attacks of the immune system. As a consequence, biofilm formation is often associated with chronic infections or bacterial colonisation of medical implants that are refractory to antibiotic treatment. In addition, some biofilm-related proteins as e.g. curli fibres are highly inflammatory. Anti-biofilm compounds are sought after intensively. Since living organisms are likely to protect themselves against being colonized by bacterial biofilms, one may expect to find compounds with anti-biofilm activities in plants, animals, algae or other microorganisms.


Principal Investigators
Hengge, Regine Prof. Dr. (Details) (Microbiology)

Duration of Project
Start date: 08/2018
End date: 12/2020

Publications
Hengge. R. (2019) Targeting of bacterial biofilms by the green tea polyphenol EGCG. Molecules 24: 2403. doi: 10.3390/molecules24132403.

Last updated on 2021-04-01 at 17:47