Temperature Dependence of Neural Computation
Neuronal processing depends on temperature. Although in mammals large temperature deviations are prevented by the central regulation of body temperature, the temperature of the healthy brain is subject to fluctuations on the order of two degrees Celsius. Such variations are even more pronounced under pathological conditions like fever or hypothermia. Temperature affects physico-chemical processes in the brain and hence modulates electrical activity of neurons. The aim of the project is to investigate the consequences of temperature changes on neural processing and to identify mechanisms that enable nervous systems to retain their functionality despite temperature fluctuations.
Neuronal processing depends on temperature. Although in mammals large temperature deviations are prevented by the central regulation of body temperature, the temperature of the healthy brain is subject to fluctuations on the order of two degrees Celsius. Such variations are even more pronounced under pathological conditions like fever or hypothermia. Temperature affects physico-chemical processes in the brain and hence modulates electrical activity of neurons. The aim of the project is to investigate the consequences of temperature changes on neural processing and to identify mechanisms that enable nervous systems to retain their functionality despite temperature fluctuations.
Financer
Duration of project
Start date: 10/2014
End date: 12/2022
Publications
Pfeiffer P, Egorov AV, Lorenz F, Schleimer J-H, Draguhn A, Schreiber S (2020): Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory. eLife 2020;9:e49974.
Michalikova M, Remme MWH, Schmitz D, Schreiber S, Kempter R (2019): Spikelets in pyramidal neurons: generating mechanisms, distinguishing properties, and functional implications. Reviews in the Neurosciences, 20190044, ISSN (Online) 2191-0200.
Ferrarese L, Jouhanneau J-S, Remme MWH, Kremkow J, Katona G, Rózsa B, Schreiber S, Poulet J (2018): Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo. Cell Reports, 24, 3455-3465.e5.
Schleimer J-H, Schreiber S (2018): Phase-response curves of ion channel gating kinetics. Math Meth Appl Sci 41, 8844-8858.
Hesse J, Schleimer J-H, Schreiber S (2017): Qualitative changes in phase-response curve and synchronization at the saddle-node loop bifurcation. Phys Rev E, 95, 052203.
Wilmes KA, Schleimer J-H, Schreiber S (2016): Spike-timing dependent inhibitory plasticity to learn a selective gating of backpropagating action potentials. European Journal of Neuroscience, 45: 1032-1043; doi:10.1111/ejn.13326.
Wilmes KA, Sprekeler* H, Schreiber* S (2016): Inhibition as a binary switch for excitatory plasticity in pyramidal neurons. PLoS Comput Biol 12(3): e1004768. doi:10.1371/journal.pcbi.1004768. *Equal contribution.
Ebbesen CL, Reifenstein ET, Tang Q, Burgalossi A, Ray S, Schreiber S, Kempter R, Brecht M (2016): Cell type-specific differences in spike timing and spike shape in rat parasubiculum and superficial medial entorhinal cortex. Cell Reports; http://dx.doi.org/10.1016/j.celrep.2016.06.057.
Reifenstein E, Ebbesen CL, Tang Q, Brecht M, Schreiber S, Kempter R (2016): Cell-type specific phase precession in layer II of the medial entorhinal cortex. The Journal of Neuroscience, 36(7): 2283-2288; doi: 10.1523/JNEUROSCI.2986-15.2016.
Blankenburg S, Wu W, Lindner B, Schreiber S (2015): Information filtering in resonant neurons. Journal of Computational Neuroscience, 39(3), 349-370, doi:10.1007/s10827-015-0580-6.
Rau F, Clemens J, Naumov V, Hennig RM, Schreiber S (2015): Firing-rate resonances in the peripheral auditory system of the cricket, Gryllus bimaculatus. J Comp Physiol A, doi: 10.1007/s00359-015-1036-1.
