Genetic Variation of Kappa-Casein in Sudanese Goats


The aim of this study is to characterize four Sudanese goat breeds, identify genetic variation of the diacylglycerol acyltransferase 1 (DGAT1) gene and the milk protein genes alpha-S1 casein (CSN1S1), alpha-S2 casein (CSN1S2), beta casein (CSN2), kappa casein (CSN3), alpha-lactalbumin (LALBA), and milk beta-lactoglobulin (MBLG), perform an association study between sequence variation and milk yield and composition, and to investigate the genetic diversity among Saanen and Sudanese goat breeds using the goat SNP50 Beadchip. The proposed breeds include four Sudanese indigenous breeds (Nubian, Nilotic, Desert and Dwarf goats) and the exotic Saanen goat as a control group (100 from each native breed and 50 from Saanen dairy goats). Milk yield and composition, reproductive performance, morphological characteristics and longevity are recorded as phenotypes. Candidate genes will be comparatively sequenced and sequence variation will be used for association tests. For assessing the genetic diversity among goat breeds, eight to ten animals per breed will be genotyped genome-wide, using the goat SNP50 BeadChip from Illumina. The long term goal of this study is the identification of selection markers to improve the productivity of native goats in developing countries, especially under the environmental conditions in Sudan.


Principal Investigators
Brockmann, Gudrun A. Prof. Dr. rer. nat. habil. (Details) (Breeding Biology and Molecular Animal Breeding)

Duration of Project
Start date: 08/2015
End date: 10/2018

Publications
1. Ahmed AS, Rahmatalla S, Bortfeldt R, Arends D, Reissmann M, Brockmann GA: Milk protein polymorphisms and casein haplotypes in Butana cattle. Journal of applied genetics 2016:1-11.
2. Rahmatalla SA, Arends D, Reissmann M, Said Ahmed A, Wimmers K, Reyer H, Brockmann GA: Whole genome population genetics analysis of Sudanese goats identifies regions harboring genes associated with major traits. BMC genetics 2017, 18(1):92.
3. Hassan LMA, Arends D, Rahmatalla SA, Reissmann M, Reyer H, Wimmers K, Abukashawa SMA, Brockmann GA: Genetic diversity of Nubian ibex in comparison to other ibex and domesticated goat species. European Journal of Wildlife Research 2018, 64(5):52.
4. Rahmatalla S, Arends D, Reissmann M, Wimmers K, Reyer H, Brockmann G: Genome-wide association study of body morphological traits in Sudanese goats. Animal Genetics 2018, 49.
5. Rahmatalla SA, Arends D, Ahmed AS, Reissmann M, Brockmann GA: Whey protein polymorphisms in Sudanese goat breeds. Tropical Animal Health and Production 2019.

Last updated on 2020-21-10 at 13:49