Neurocognitive Dysfuntions of Tic-related Obsessive-compulsive Disorder


OCD is a heterogeneous disorder and it is assumed that this heterogeneity hampers the identification of etiological mechanisms. Accordingly, a research priority in OCD is the refinement of the nosology. One approach refers to the identification of subtypes, i.e. the dissection of the phenotype into more homogenous groups based on specific features. OCD with comorbid lifetime diagnosis of chronic tic-disorders (TD) differs from pure OCD. It is assumed that this tic-related OCD subtype is etiologically related to TD. This could be reflected in different mechanisms underlying compulsions of tic-related and tic-free OCD: tic-related OCD more frequently involves the occurrence of sensory phenomena (e.g disturbing sensations and urges) preceding or accompanying their compulsions. This is similar to chronic TD. Tic-free OCD is more frequently motivated by harm avoidance. The present project aims at examining whether these differences can be linked to neurocognitive dysfunctions. Sensory phenomena are assumed to be the result of deficient sensory gating mechanisms. This will be examined with the prepulse inhibition paradigm. The avoidance of harm or negative outcomes will be assessed with a probabilistic selection task allowing to measure sensitivity towards negative feedback. Finally, impaired response inhibition as a mechanism potentially underlying repetitive behaviour is examined. OCD, but not chronic TD, is associated with prolonged stop signal reaction times. Given the presumed etiological relationship between chronic TD and tic-related OCD it is investigated whether response inhibition is also intact in tic-related OCD. These paradigms will be tested in 24 tic-related OCD patients, 24 tic-free OCD patients, and 24 healthy controls. At least 20 patients with chronic TD will be included as clinical control group. It is expected that tic-related OCD is associated with a specific profile of neurocognitive dysfunctions. Compared to tic-free OCD, some dysfunctions are expected to be absent (repressive model) whereas others are quantitatively altered.


Spokesperson
Kloft, Lisa Dr. (Details) (Clinical Psychology)

Duration of Project
Start date: 04/2015
End date: 05/2019

Research Areas
Differential, Clinical and Medical Psychology, Methodology

Last updated on 2021-15-07 at 13:11