CRC 1315/1: SP A01 – Control of Memory Engram-Related Activity in the Hippocampus: Focus on Disinhibition

Hippocampal sharp wave/ripple complexes (SWRs, Buzsaki, 1989) are short (50-100 ms) episodes of coordinated network activity arising in the hippocampal CA3 area. They may mediate the consolidation of explicit memories, and their disruption interferes with memory (Girardeau et al. 2009). However, the mechanisms governing the occurrence of these episodes remain obscure. To understand the functional role of SWRs in memory consolidation, we will focus on mechanisms that control the rapid onset and termination and the incidence of the sharp-wave (SPW) component. We propose that disinhibition governs the underlying network dynamics and plan to evaluate this hypothesis by developing a computational model that will be analyzed mathematically. The model will be constrained by experiments, in vitro, and its predictions will be tested experimentally.

Principal Investigators
Kempter, Richard Prof. Dr. (Details) (Computational Neuroscience)
Schmitz, Dietmar Prof. Dr. (Charité – Universitätsmedizin Berlin)

Duration of Project
Start date: 07/2018
End date: 06/2022

M. Michalikova, M. Remme, D. Schmitz, S. Schreiber, R. Kempter. Spikelets in pyramidal neurons: generating mechanisms, distinguishing properties, and functional implications. Rev. Neurosci., 10.1515/revneuro-2019-0044.

T. McColgan, P.T. Kuokkanen, C.E. Carr, R. Kempter. Dynamics of synaptic extracellular field potentials in the nucleus laminaris of the barn owl. J. Neurophysiol., 121:1034-1047, 2019.

R. Evangelista, 2019: Network mechanisms regulating the generation of sharp wave-ripple complexes in the hippocampus. The role of disinhibition in three-population models. Dissertation an der Lebenswissenschaftlichen
Fakultät der Humboldt-Universität zu Berlin. DOI:10.18452/20567

A. Holzbecher, R. Kempter. Interneuronal gap junctions increase synchrony and robustness of hippocampal ripple oscillations. Eur. J. Neurosci., 48: 3446-3465, 2018.

Last updated on 2021-19-03 at 13:05