Einstein International Postdoctoral Fellow Michiel Remme
Ziel des Projektes ist es, mit Hilfe mathematischer Beschreibung einzelner Nervenzellen grundlegende Prinzipien neuronaler Signalverarbeitung zu erkennen. Im Fokus steht das Zusammenspiel von zell-intrinsischen Eigenschaften und der raeumlichen Verteilung synaptischer Eingangssignale über den Dendritenbaum.
Mittelgeber
Einstein Stiftung Berlin
Laufzeit
Projektstart: 07/2012
Projektende: 05/2016
Publikationen
Michalikova M, Remme MWH, Schmitz D, Schreiber S, Kempter R (2019): Spikelets in pyramidal neurons: generating mechanisms, distinguishing properties, and functional implications. Reviews in the Neurosciences, 20190044, ISSN (Online) 2191-0200.
Remme MWH, Rinzel J, Schreiber S (2018): Function and energy consumption constrain neuronal biophysics in a canonical computation: Coincidence detection. PLoS Comput Biol 14(12): e1006612.
Michalikova M, Remme M, Kempter R, (2018): Extracellular waveforms reveal an axonal origin of spikelets in pyramidal neurons. J. Neurophysiol., 120: 1484-1495.
Ferrarese L, Jouhanneau J-S, Remme MWH, Kremkow J, Katona G, Rózsa B, Schreiber S, Poulet J (2018): Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo. Cell Reports, 24, 3455-3465.e5.
Ness TV, Remme MWH, Einevoll GT (2018): h-type membrane current shapes the local field potential from populations of pyramidal neurons. Journal of Neuroscience 38 (26), 6011-6024
Aspart F, Remme MWH, Obermayer K (2018): Differential polarization of cortical pyramidal neuron dendrites through weak extracellular fields. PLoS computational biology 14 (5), e1006124
Michalikova M, Remme M, Kempter R, (2017): Spikelets in pyramidal neurons: Action potentials initiated in the axon initial segment that do not activate the soma. PLoS Comput. Biol., 13(1): e1005237.
Ness TV, Remme MWH, Einevoll GT (2015): Active subthreshold dendritic conductances shape the local field potential. The Journal of physiology 594 (13), 3809-3825
Zhuchkova E, Remme M, Schreiber S (2013): Subthreshold resonance and membrane potential oscillations in a neuron with nonuniform active dendritic properties. In: The Computing Dendrite. Springer Series in Computational Neuroscience . 331-346
Zhuchkova E, Remme MWH, Schreiber S (2013): Somatic versus dendritic resonance: differential filtering of inputs through non-uniform distributions of active conductances. PLoS ONE 8(11): e78908.
Remme MWH, Lengyel M, Gutkin BS (2013): A trade-off between dendritic democracy and independence in neurons with intrinsic subthreshold membrane potential oscillations. The Computing Dendrite, 347-364
