US-German Research Proposal: Collaborative Research: Field Potentials in the Auditory System


Extracellular field potentials are typically generated by various neuronal sources, making their interpretation difficult. They are, however, clinically important, with applications ranging from diagnostics to brain-computer interfaces. In the auditory system, for example, the auditory evoked potential, also called the auditory brainstem response (ABR), is widely used for newborn hearing screening but little is known how specific nuclei contribute to its structure. Given the clinical relevance and theoretical importance of understanding extracellular field potentials, we proposed a combined computational and neurophysiological investigation of the extracellular field potential in a bird model system. The structure is homogeneous and well organized, and allows direct access to a system with a large extracellular field potential. Our models and experiments will delineate the potential contributions of the three possible sources of the extracellular field potentials. The approach tightly integrates theory and experiments, to provide a fundamental understanding of the connection between the extracellular field potentials and their neuronal generators. In particular, results will provide a basis for the interpretation of the clinically relevant ABR.


Principal Investigators
Kempter, Richard Prof. Dr. (Details) (Computational Neuroscience)

participating organizational facilities of the HU

Duration of Project
Start date: 09/2017
End date: 08/2019

Research Areas
Life Sciences

Research Areas
Computational Neuroscience

Publications
T. McColgan, P.T. Kuokkanen, C.E. Carr, R. Kempter. Dynamics of synaptic extracellular field potentials in the nucleus laminaris of the barn owl. J. Neurophysiol., 121:1034-1047, 2019.

P.T. Kuokkanen, A. Kraemer, R. Kempter, C. Koeppl, C.E. Carr. Auditory brainstem response wave III is correlated with extracellular field potentials from nucleus laminaris of the barn owl. Acta Acust. united Ac., 104: 874-877, 2018.

P.T. Kuokkanen, G. Ashida, A. Kraemer, T. McColgan, K. Funabiki, H. Wagner, C. Koeppl, C.E. Carr, R. Kempter. Contribution of action potentials to the extracellular field potential in the nucleus laminaris of barn owl. J. Neurophysiol., 119: 1422-1436, 2018.

T. McColgan, J. Liu, P.T. Kuokkanen, C.E. Carr, H. Wagner, R. Kempter. Dipolar extracellular potentials generated by axonal projections. eLife 2017;6:e26106.

C. E. Carr, G. Ashida, H. Wagner, T. McColgan, R. Kempter. The role of conduction delay in creating sensitivity to interaural time differences. In P. van Dijk et al. (eds.), Physiology, Psychoacoustics and Cognition in Normal and Impaired Hearing, Advances in Experimental Medicine and Biology 894, 2016.

Last updated on 2020-11-11 at 10:48