Einstein Visiting Fellowship Detlef Günther - Analysis of Nanoparticles and Cells

Due to the rapid growth of nano- and microparticle applications and (consumer) products in science, industry, and medicine there is a strongly increasing interest in new methodologies and instrumentations for monitoring and chemical characterization. A quantitative assessment of end-of-life cycles of these materials in order to lower environmental impact and risk for human health. Few is known about health related issues and their fate in the environment which might include aggregation with other materials, change of nature or disintegration into smaller species. A wide variety of techniques have already been tested for the characterization of composition, mass and number of particles. However, quantification remains challenging and is currently by far not routine and a fast and sensitive detection method is still missing in the analytical toolbox. The common interest between the research group at ETH Zurich and research groups at Humboldt-Universität zu Berlin, especially within the framework of the graduate school (SALSA), is related to the characterization of engineered and laser generated aerosols and is focused on the development of quantitative methods for nanoparticle research. These fundamental and applied research programs have implications for environmental science and material science, geology and climate studies, and are currently entering dedicated research programs in medicine and biology. The project will therefore be devoted to single droplet introduction into elemental mass spectrometry, ICP-MS, for the quantification of nanoparticles and cells as biological particles. The quantification will be based on synthetic multielement solutions which eliminates currently required nanoparticle reference materials. Furthermore, matrix effects within the ICP will be studied using different multielement solutions. The studies on laser-generated aerosols will be directed towards high spatial resolution analysis of tissues. The proposed project led by one of the most renowned scientists in the field will provide fundamental insight for nanoparticle research and will further enhance the international visibility of SALSA and the research campus Adlershof

Principal Investigators
Panne, Ulrich Prof. Dr. rer. nat. (Details) (Graduate School for Analytical Sciences Adlershof (SALSA))

Duration of Project
Start date: 04/2013
End date: 03/2015

Last updated on 2021-18-01 at 11:55